中华肝胆外科杂志
中華肝膽外科雜誌
중화간담외과잡지
CHINESE JOURNAL OF HEPATOBILIARY SURGERY
2009年
1期
20-21
,共2页
马仁%花瞻%项汕宏%周雷%王文跃
馬仁%花瞻%項汕宏%週雷%王文躍
마인%화첨%항산굉%주뢰%왕문약
胆囊切除术%Megalin分子%胆囊上皮细胞
膽囊切除術%Megalin分子%膽囊上皮細胞
담낭절제술%Megalin분자%담낭상피세포
Cholecystitis%Megalin mRNA%Gallbladder epithelium
目的 探讨和分析Megalin mRNA在胆石症病人胆囊上皮细胞的表达变化及其意义.方法 检测62例胆结石和38例胆囊息肉病人胆囊内皮细胞的Megalin mRNA表达水平,应用RT-PCR分析Megalin的表达.结果 发现胆结石病人胆囊上皮细胞表达Megalin mRNA水平远低于胆囊息肉病人的水平,同时检测两组病人血清胆固醇水平的结果 显示血清胆固醇无差别.结论 胆囊上皮吸收胆固醇机制可能在胆结石的病理发生过程中有重要的意义.
目的 探討和分析Megalin mRNA在膽石癥病人膽囊上皮細胞的錶達變化及其意義.方法 檢測62例膽結石和38例膽囊息肉病人膽囊內皮細胞的Megalin mRNA錶達水平,應用RT-PCR分析Megalin的錶達.結果 髮現膽結石病人膽囊上皮細胞錶達Megalin mRNA水平遠低于膽囊息肉病人的水平,同時檢測兩組病人血清膽固醇水平的結果 顯示血清膽固醇無差彆.結論 膽囊上皮吸收膽固醇機製可能在膽結石的病理髮生過程中有重要的意義.
목적 탐토화분석Megalin mRNA재담석증병인담낭상피세포적표체변화급기의의.방법 검측62례담결석화38례담낭식육병인담낭내피세포적Megalin mRNA표체수평,응용RT-PCR분석Megalin적표체.결과 발현담결석병인담낭상피세포표체Megalin mRNA수평원저우담낭식육병인적수평,동시검측량조병인혈청담고순수평적결과 현시혈청담고순무차별.결론 담낭상피흡수담고순궤제가능재담결석적병리발생과정중유중요적의의.
Objective To detect and analyze the change of Meaglin mRNA expression in gall-bladder epithelium of the cholelithiasis and gallbladder polyp patients. Methods The expression level of Megalin mRNA was determined in 62 ceses of cholelithiasis and 38 cases of gallbladder polyp by RT-PCR. Results Megalin mRNA was expressed in the gallbladder epithelium and the expression was significantly different between the 2 groups. Conclusion The mechanism of cholesterol absorp-tion in gallbladder epithelium might play an important role in gallstone pathogenesis.
