CAJ | 학술논문

目的探讨子宫颈微偏腺癌及子宫颈微腺体增生的临床和病理特点.方法对2例子宫颈微偏腺癌及1例子宫颈微腺体增生患者临床资料和免疫组化染色结果进行分析.结果微偏腺癌临床表现为大量水样白带,肉眼观察子宫颈增粗,切面见大小不一、含有黏液的囊腔;而微腺体增生宫颈无明显异常.结论微偏腺癌是宫颈的恶性病变,分化好,预后差;微腺体增生是一种完全良性病变.
목적 탐토자궁경미편선암급자궁경미선체증생적림상화병리특점.방법 대2례자궁경미편선암급1례자궁경미선체증생환자림상자료화면역조화염색결과진행분석.결과미편선암림상표현위대량수양백대,육안관찰자궁경증조,절면견대소불일、함유점액적낭강;이미선체증생궁경무명현이상.결론 미편선암시궁경적악성병변,분화호,예후차;미선체증생시일충완전량성병변.
Objective To discuss the features,such as clinical symptoms,pathologic morphologies,immunohistochemical staining of minimal deviation adenocarcinoma and microglandular hyperplasia of the uterine cervix in order to improve the accuracy of pathological diagnosis.Methods s:Histopathologic characteristics of total hysterectomies in 2 cases of minimal deviation adenocarcinoma and 1 case of cervical microglandular hyperplasia based on the formalin-fixed,paralfin-embedded and hematoxylin-eosin stained tissue were analyzed retrospectively.Immunohistochemical staining was used to detect the expression of CEA,p53,PCNA,and Ki-67 in all 3 cases.Results The main clinical symptoms of minimal deviation adenocarcinoma were watery leucorrhea and enlargement of the cervix.The pathological findings of MDA included hyperplasia of the glands with cytological minimal atypia,invasion effects into the stroma could be observed in some glands and abortive glands with desmoplastic changes,or edema and inflammatory infiltration around the glands were also observed.The invasion presented in the deep part of the cervix as well.The patiant of MGH had a history of oval contraceptive use.Histological features of MGH included tightly packed glands in different sizes and shapes,presentation of inflammatory cells in stroma and glandular lumens,and focal epithelial cell pleomorphism and hyperchromatism but without mitosis.CEA was positive in all two MDA cases,but the tissue of MGH was negative for CEA.The expressions of the other four markers had no difference between MDA and MGH.Conclusions For patients with watery discharge and/or hypertrophy of cervix,the deep ( ＞ 5 mm ) biopsies should be performed.The immunohistochemical staining for CEA,p53,CA125 and ER has adjuvant diagnostic values.It is extremely important to recognize that MGH is an entirely benign lesion.