CAJ | 학술논문

本实验分别给予100例肾移植术后患者预防性应用抗胸腺淋巴细胞球蛋白(ATG)和100例肾移植术后常规应用环孢素A(CsA)组进行了持续三个月的临床研究.结果表明:应用ATG组肾功能恢复快(3～10天,CsA组7～15天);急性排斥率低(ATG组18%,CsA为47%);肾中毒ATG组无,而CsA组15例(P<0.001),有显著差别;肝中毒及感染发生率无显著差别(P>0.05).在应用ATG过程中同时测定了血清IL-6、SIL-2R活性,结果ATG组较CsA组明显升高.本文还对ATG与CsA、IL-6、SIL-2R关系以及ATG对移植后预防价值进行讨论.
본실험분별급여100례신이식술후환자예방성응용항흉선림파세포구단백(ATG)화100례신이식술후상규응용배포소A(CsA)조진행료지속삼개월적림상연구.결과표명:응용ATG조신공능회복쾌(3～10천,CsA조7～15천);급성배척솔저(ATG조18%,CsA위47%);신중독ATG조무,이CsA조15례(P<0.001),유현저차별;간중독급감염발생솔무현저차별(P>0.05).재응용ATG과정중동시측정료혈청IL-6、SIL-2R활성,결과ATG조교CsA조명현승고.본문환대ATG여CsA、IL-6、SIL-2R관계이급ATG대이식후예방개치진행토론.
A 3-month study on the comparison between 100 cadaveric kidrey transplant recipients immunosuppressed with ATG and 100 control recipients with standard CsA regimen have been conducted.The results showed that the ATG group had a quicker graft function recovery(3 ～10 days to 7～15 days),lower acute rejection rate(18%to 47%)and no nephrotoxicity(0 to15 cases,P<0.001).But the incidences of hepatoxicity and infection showed no difference between the two groups.Higher serum levels of IL-6 and SIL-2R were observed in ATG group.The relationship of ATG with CsA,IL-6 and SIL-2R,and the ATG value in preventing acute rejection were discussed.