中国海洋湖沼学报(英文版)
中國海洋湖沼學報(英文版)
중국해양호소학보(영문판)
Chinese Journal of OCEANOLOGY and LIMNOLOGY
2003年
4期
324-328
,共5页
张全斌%李智恩%周革非%牛锡珍%张虹
張全斌%李智恩%週革非%牛錫珍%張虹
장전빈%리지은%주혁비%우석진%장홍
Laminaria japonica%fucoidan%delayed-type hypersensitivity%humoral immunity
Effects of fucoidan from Laminaria japonica on 2,4-dinitrochlorobenzene induced delayed-type hypersensitivity (DTH) reaction and the serum levels of IgG, IgM, complement C3 and C4 were investigated in the present study. Results showed that oral administration of fucoidan at dose of 150 and 300 mg/(kg*d) for 9 days before the hapten challenge significantly inhibited 2,4-dinitrochlorobenzene induced delayed-type hypersensitivity reaction; and also inhibited the humoral immunity. Serum C3 and C4 levels were markedly reduced by fucoidan at dose of 150 and 300 mg/kg; and serum IgG and IgM levels were reduced by fucoidan at dose of 300 mg/kg. The inhibitory effects of fucoidan on delayed-type hypersensitivity suggested that it may be potential medication for chronic inflammatory diseases in the future.
