中国实用医药
中國實用醫藥
중국실용의약
CHINA PRACTICAL MEDICAL
2009年
16期
9-10
,共2页
2型糖尿病(NIDDM)%他汀类%C-反应蛋白(CRP)%甘油三酯(TG)%总胆固醇(TC)%纤维蛋白原(Fg)%D-二聚体(D-dimer)
2型糖尿病(NIDDM)%他汀類%C-反應蛋白(CRP)%甘油三酯(TG)%總膽固醇(TC)%纖維蛋白原(Fg)%D-二聚體(D-dimer)
2형당뇨병(NIDDM)%타정류%C-반응단백(CRP)%감유삼지(TG)%총담고순(TC)%섬유단백원(Fg)%D-이취체(D-dimer)
Noninsulin-dependent Diabetes Mellitus (NIDDM)%Simvastatin%C-reactive protein (CRP)%Triglyceride(TG)%Total Cholesterol(TC)%fibrinogen%D-dimer
目的 探讨他汀类药物对2型糖尿病(NIDDM)患者凝血功能及血管内皮炎性的影响.方法 113例NIDDM患者,其中观察组53例口服辛伐他汀合并阿司匹林.对照组60例仅口服阿司匹林.分别对两组在服用辛伐他汀8周前后采血检测空腹血糖(FPG)、血浆纤维蛋白原(Fg)、D-二聚体(D-dimer), C-反应蛋白(CRP)、甘油三酯(TG),总胆固醇(TC),高密度脂蛋白胆固醇(HDL) 和低密度脂蛋白胆固醇(LDL).结果 观察组服用辛伐他汀8周后TC, TG,LDL和CRP较服药前均明显降低(P<0.05).Fg和D-dimer服药前后无显著性差异(P>0.05).结论 他汀类药物能明显改善糖尿病患者血脂胆固醇水平及血管内皮炎性反应,对防治并发症具有临床指导意义.
目的 探討他汀類藥物對2型糖尿病(NIDDM)患者凝血功能及血管內皮炎性的影響.方法 113例NIDDM患者,其中觀察組53例口服辛伐他汀閤併阿司匹林.對照組60例僅口服阿司匹林.分彆對兩組在服用辛伐他汀8週前後採血檢測空腹血糖(FPG)、血漿纖維蛋白原(Fg)、D-二聚體(D-dimer), C-反應蛋白(CRP)、甘油三酯(TG),總膽固醇(TC),高密度脂蛋白膽固醇(HDL) 和低密度脂蛋白膽固醇(LDL).結果 觀察組服用辛伐他汀8週後TC, TG,LDL和CRP較服藥前均明顯降低(P<0.05).Fg和D-dimer服藥前後無顯著性差異(P>0.05).結論 他汀類藥物能明顯改善糖尿病患者血脂膽固醇水平及血管內皮炎性反應,對防治併髮癥具有臨床指導意義.
목적 탐토타정류약물대2형당뇨병(NIDDM)환자응혈공능급혈관내피염성적영향.방법 113례NIDDM환자,기중관찰조53례구복신벌타정합병아사필림.대조조60례부구복아사필림.분별대량조재복용신벌타정8주전후채혈검측공복혈당(FPG)、혈장섬유단백원(Fg)、D-이취체(D-dimer), C-반응단백(CRP)、감유삼지(TG),총담고순(TC),고밀도지단백담고순(HDL) 화저밀도지단백담고순(LDL).결과 관찰조복용신벌타정8주후TC, TG,LDL화CRP교복약전균명현강저(P<0.05).Fg화D-dimer복약전후무현저성차이(P>0.05).결론 타정류약물능명현개선당뇨병환자혈지담고순수평급혈관내피염성반응,대방치병발증구유림상지도의의.
Objective To study the anti-inflammatory and anticoagulant effects of simvastatin in patients with noninsulin-dependent diabetes mellitus(NIDDM). Methods 113 patients were divided into two groups. 53 patients in study group were designed with an 8-week intervention period with simvastatin and aspirin. 60 patients in control groups had no intervention as normal with aspirin. We evaluated fasting plasma glucose, plasma fibrinogen level, D-dimer, and C-reactive protein (CRP) triglyceride(TG), total, high density lipoprotein (HDL), and low density lipoprotein (LDL) cholesterol in blood samples drawn after fasting on day 0 and after 8 weeks. Results Significant reductions of total cholesterol(P<0.01), LDL cholesterol(P< 0.05), triglycerides (P< 0.05) and CRP (P<0.05)were achieved after 8 weeks of treatment with simvastatin. Levels of fibrinogen and D-dimer did not decrease after treatment with simvastatin (P>0.05).Conclusion The results indicated that simvastatin reduces levels of TC , TG and inflammation markers in type 2 diabetic patients. These effects of treatment with statins could play a role in reducing vascular complications in patients with NIDDM.
