CAJ | 학술논문

恶性多形性胶质母细胞瘤(GBM)--恶性度最高的WHO Ⅳ级神经胶质瘤是发病率最高的原发型脑肿瘤.EGFR酪氨酸激酶介导的信号转导与肿瘤发生发展密切相关,抑制该受体活性可以有效抑制肿瘤.近年来,许多以此为靶点的新抗肿瘤药物被陆续开发,在多种肿瘤治疗中取得了令人鼓舞的疗效.
악성다형성효질모세포류(GBM)--악성도최고적WHO Ⅳ급신경효질류시발병솔최고적원발형뇌종류.EGFR락안산격매개도적신호전도여종류발생발전밀절상관,억제해수체활성가이유효억제종류.근년래,허다이차위파점적신항종류약물피륙속개발,재다충종류치료중취득료령인고무적료효.
Glioblastoma multiform(GBM)-The most malignant type of glioma(WHO grade Ⅳ),is the most frequent primary brain tumor.The signal transduction of epidermal growth factor receptor tyrosine kinase(TK)is closely associated with tumor progression.Recently,novel antineoplastics were developed by preferentially targeting inhibition of such EGFR tyrosine kinase.