CAJ | 학술논문

近20年来,治疗性单克隆抗体已经成为重要的生物技术药物,具有极大的开发应用价值.目前治疗性单克隆抗体的研发技术主要有转基因小鼠、鼠源抗体改造、抗体库、杂交瘤、B细胞永生化,以及B细胞移植等平台.这些技术平台发展迅速、各具特色,为治疗性单克隆抗体的开发提供了丰富多样的研究策略.
근20년래,치료성단극륭항체이경성위중요적생물기술약물,구유겁대적개발응용개치.목전치료성단극륭항체적연발기술주요유전기인소서、서원항체개조、항체고、잡교류、B세포영생화,이급B세포이식등평태.저사기술평태발전신속、각구특색,위치료성단극륭항체적개발제공료봉부다양적연구책략.
In the last decade, therapeutic monocional antibodies have developed into an important kind of bio-technological drugs with great benefits and profits in clinical applications. At present, the technology in the pro-duction of therapeutic monoclonal antibodies mainly consist of transgenic mouse, reforming of murine antibody, antibody library, hybridoma, B cell immortalization, and B cell transplantation. These platforms develop rapid-ly with different technological features, and provide a variety of strategies for the development of therapeutic monoclonal antibodies.