CAJ | 학술논문

目的探讨冲动暴力行为与相关短串联重复序列基因座的关联情况.方法运用AmpFISTR IdentifilerTM荧光标记复合扩增体系,对203例冲动暴力行为罪犯(研究组)与207名非暴力行为健康个体(对照组)样本进行聚合酶链反应复合扩增,然后应用ABI3100型基因分析系统对扩增产物进行电泳和基因检测,观察2组15个STR基因座等位基因及基因型频率的差异.结果 15个STR基因座均符合遗传平衡定律(Hardy-Weinberg定律)；研究组与对照组THO1和TPOX基因座的等位基因频率分布的差异有统计学意义(P＜0.05)；研究组和对照组THO1-10频率分别为0.0172和0.0580,差异有统计学意义(P=0.002,OR=0.29,95％ CI:0.12 ～0.67)；研究组和对照组TPOX-11频率分别为0.3621和0.2391,差异有统计学意义(P=0.000,OR=1.81,95％ CI:1.33 ～ 2.45)；其他STR基因座等位基因频率及所有基因型频率2组差异均无统计学意义(P＞0.05).结论 THO1和TPOX基因座多态性与冲动暴力行为可能存在关联,等位基因THO1-10、TPOX-11与冲动暴力行为的发生可能有一定关系.
목적 탐토충동폭역행위여상관단천련중복서렬기인좌적관련정황.방법 운용AmpFISTR IdentifilerTM형광표기복합확증체계,대203례충동폭역행위죄범(연구조)여207명비폭역행위건강개체(대조조)양본진행취합매련반응복합확증,연후응용ABI3100형기인분석계통대확증산물진행전영화기인검측,관찰2조15개STR기인좌등위기인급기인형빈솔적차이.결과 15개STR기인좌균부합유전평형정률(Hardy-Weinberg정률)；연구조여대조조THO1화TPOX기인좌적등위기인빈솔분포적차이유통계학의의(P＜0.05)；연구조화대조조THO1-10빈솔분별위0.0172화0.0580,차이유통계학의의(P=0.002,OR=0.29,95％ CI:0.12 ～0.67)；연구조화대조조TPOX-11빈솔분별위0.3621화0.2391,차이유통계학의의(P=0.000,OR=1.81,95％ CI:1.33 ～ 2.45)；기타STR기인좌등위기인빈솔급소유기인형빈솔2조차이균무통계학의의(P＞0.05).결론 THO1화TPOX기인좌다태성여충동폭역행위가능존재관련,등위기인THO1-10、TPOX-11여충동폭역행위적발생가능유일정관계.
Objective To investigate the association of aggressive violent behavior and related short tandem repeats (STRs) loci by the analysis of 15 STRs loci genetic polymorphism.Methods The biological samples of 203 persons with aggressive violent behaviors and 207 healthy persons without violent behavior were collected.Then the DNA sample was amplified by AmpFISTR IdentifilerTM system and separated by electrophoresis to compare the genotypes and alleles of 15 STRs gene frequencies in the two groups.Results All the 15 STRs loci in people with aggressive violent behavior and healthy people were found to coincide with Hardy-Weinberg equilibrium ( P ＞ 0.05 ).There was a significant difference in distributing of allele frequency of THO1 and TPOX between people with aggressive violent behaviors and healthy people ( P ＜ 0.05 ).The frequency of allele 10 of THO1 ( aggressive violent offenders:0.0172 ;control group:0.0580) was significantly different in the two groups ( P =0.002,OR =0.29,95％ CI:0.12 - 0.67 ).The frequency of allele 11 of TPOX (people with aggressive violent behaviors:0.3621; healthy people:0.2391 )was significantly different between the two groups( P =0.000,OR =1.81,95％ CI:1.33 -2.45).There was not a statistical difference in other STRs loci allele frequencies and all the STRs genotype frequencies between the two groups ( P ＞ 0.05 ).Conclusion The genetic polymorphism of THO1 and TPOX loci may be associated with the aggressive violent behaviors,and the allele 10 of THO1,allele 11 of TPOX may be the genetic factor to aggressive violent behavior.