CAJ | 학술논문

目的观察重症急性胰腺炎(SAP)患者血浆内皮素(ET)水平的变化特点及参麦对其影响.方法按照平行对照设计原理,将所有60名患者分为常规治疗组(A组)和常规治疗+参麦治疗组(B组).对两组患者的相关临床资料及ET水平进行比较.结果与B组患者比较,A组患者第2天、第4天ET水平均明显升高[(80.36±11.05)比(98.18±11.83)、(93.63±8.59)比(107.53±9.26)](P均＜0.05)；与B组患者比较,A组患者第7天ET水平明显升高(76.25±10.81比93.17±12.42)(P＜0.01)；与B组患者比较,A组患者治疗前ET水平两组差异无统计学意义(P＞0.05)；与B组患者比较,A组患者年龄、性别、APACHEⅡ评分等两组差异无统计学意义(P均＞0.05).结论参麦注射液治疗SAP可有效降低患者血浆中的ET含量,通过改善SAP患者的微循环而起到较好的治疗作用.
목적 관찰중증급성이선염(SAP)환자혈장내피소(ET)수평적변화특점급삼맥대기영향.방법 안조평행대조설계원리,장소유60명환자분위상규치료조(A조)화상규치료+삼맥치료조(B조).대량조환자적상관림상자료급ET수평진행비교.결과 여B조환자비교,A조환자제2천、제4천ET수평균명현승고[(80.36±11.05)비(98.18±11.83)、(93.63±8.59)비(107.53±9.26)](P균＜0.05)；여B조환자비교,A조환자제7천ET수평명현승고(76.25±10.81비93.17±12.42)(P＜0.01)；여B조환자비교,A조환자치료전ET수평량조차이무통계학의의(P＞0.05)；여B조환자비교,A조환자년령、성별、APACHEⅡ평분등량조차이무통계학의의(P균＞0.05).결론 삼맥주사액치료SAP가유효강저환자혈장중적ET함량,통과개선SAP환자적미순배이기도교호적치료작용.
Objective To explore the changes of plasma endothelin(ET) as well as the effects of Shenmai in patients with severe acute pancreatitis (SAP).Methods Sixty patients with SAP were collected,and divided into routine treatment group (group A) and Shenmai treatment group (group B).The clinical data and ET levels were analyzed.Results The levels of ET were significantly higher in group A than those in group B at the day 2 and 4 [ ( 80.36 ± 11.05 ) vs (98.18 ± 11.83 ),and (93.63 ± 8.59) vs ( 107.53 ± 9.26) ] ( both P ＜ 0.05 ).The levels of ET were significantly higher in group A than those in group B at the day 7 (76.25 ± 10.81 vs 93.17 ± 12.42,P ＜0.01 ).There was no significant difference between group A and group B in age,gender,andAPACHE Ⅱ score(all P＞0.05).Conclusion Shenmai injection can effectively reduce the plasma levels of ET in SAP patients,and exert its therapeutic effect through improving microcirculation of SAP patients.