世界华人消化杂志
世界華人消化雜誌
세계화인소화잡지
WORLD CHINESE JOURNAL OF DIGESTOLOGY
2009年
18期
1803-1808
,共6页
干扰素%慢性乙型肝炎%治疗%基因
榦擾素%慢性乙型肝炎%治療%基因
간우소%만성을형간염%치료%기인
Interferon%Chronic hepatitis B%Therapy%Gene
IFN-α治疗慢性乙型肝炎的反应不仅与治疗前HBV DNA载量、HBV基因型、HBV基因组的点突变以及宿主Ⅱ类HLA基因的多态性等因素有关, 而且也与患者免疫状况有关, 病毒突变株及基因表型日益受到关注. IFN抗HBV的作用机制及HBV逃逸IFN治疗的机制尚未完全明确. 本文从基因、蛋白质和细胞等方面对相关影响因素及机制进行综述.
IFN-α治療慢性乙型肝炎的反應不僅與治療前HBV DNA載量、HBV基因型、HBV基因組的點突變以及宿主Ⅱ類HLA基因的多態性等因素有關, 而且也與患者免疫狀況有關, 病毒突變株及基因錶型日益受到關註. IFN抗HBV的作用機製及HBV逃逸IFN治療的機製尚未完全明確. 本文從基因、蛋白質和細胞等方麵對相關影響因素及機製進行綜述.
IFN-α치료만성을형간염적반응불부여치료전HBV DNA재량、HBV기인형、HBV기인조적점돌변이급숙주Ⅱ류HLA기인적다태성등인소유관, 이차야여환자면역상황유관, 병독돌변주급기인표형일익수도관주. IFN항HBV적작용궤제급HBV도일IFN치료적궤제상미완전명학. 본문종기인、단백질화세포등방면대상관영향인소급궤제진행종술.
The antiviral efficacy of interferon-α(IFN-α) therapy for chronic hepatitis B (CHB) is not only related to DNA load and genetype of HBV before treatment, gene mutation of HBV and polymorphism of type II HLA in the host, but also depends on the immunity of CHB patients. Researchers pay more and more attention to the mutant strain of virus and phenotypes of genes. However, the mechanism of interferon to resist HBV and the escape mechanism of HBV against the IFN therapy have not been clarified yet. This paper reviews the mechanism of IFN therapy and the influencing factors at molecular and genetic levels.
