CAJ | 학술논문

目的建立家兔腹主动脉易损斑块模犁.方法选取30只雄性纯种新西兰大白兔,随机分为3组:球囊损伤+高脂喂养组、高脂喂养组及普通饲料喂养组.饲养12周后分别给予中国斑点蜂蛇毒和组胺药物触发,诱发斑块破裂及血栓形成.结果内膜损伤+高脂喂养组存活的8只兔中有10处病变狭窄程度超过50%,并且脂质核心较大、纤维帽厚度小于65 μm,判定以上10处病变为易损斑块.高脂喂养组中的9只仅3处可判定为易损斑块;普通饲料喂养组中未见易损斑块.结论高脂喂养后行腹主动脉球囊拉伤制作兔易损斑块模型是切实可行的方法.
목적 건립가토복주동맥역손반괴모리.방법 선취30지웅성순충신서란대백토,수궤분위3조:구낭손상+고지위양조、고지위양조급보통사료위양조.사양12주후분별급여중국반점봉사독화조알약물촉발,유발반괴파렬급혈전형성.결과 내막손상+고지위양조존활적8지토중유10처병변협착정도초과50%,병차지질핵심교대、섬유모후도소우65 μm,판정이상10처병변위역손반괴.고지위양조중적9지부3처가판정위역손반괴;보통사료위양조중미견역손반괴.결론 고지위양후행복주동맥구낭랍상제작토역손반괴모형시절실가행적방법.
Objective To establish an animal model of vulnerable plaque in abdominal aorta by pharmacological triggering of atherosclerosis in rabbits. Methods Thirty New Zealand white rabbits were randomly and equally divided into 3 groups: group A, receiving balloon injury together with high lipid diet; group B, receiving high lipid diet only, and group C, receiving regular diet only. After feeding for 12 weeks, all the rabbits in three groups underwent pharmacological triggering with Chinese Russell's viper venom (CRVV) and histamine to induce the rupture of the plaque and the formation of thrombosis. Results In 8 survival rabbits of group A, ten lesions with the stenotic degree over 50% were found, which had large lipid core with the thickness of fibrous cap being thinner than 65μm, by which these ten lesions were judged as vulnerable plaques. In 9 rabbits of group B, only 3 vulnerable plaques could be determined, while no single vulnerable plaque could be identified in the rabbits of group C. Conclusion For establishing an animal model of vulnerable plaque in abdominal aorta in rabbits, balloon injury combined with high lipid diet is a feasible and reliable method.