中国糖尿病杂志
中國糖尿病雜誌
중국당뇨병잡지
CHINESE JOURNAL OF DIABETES
2011年
2期
119-121
,共3页
秦怀波%陈云%俞丽萍%孙水云
秦懷波%陳雲%俞麗萍%孫水雲
진부파%진운%유려평%손수운
同型半胱氨酸%糖尿病,2型%降糖治疗
同型半胱氨痠%糖尿病,2型%降糖治療
동형반광안산%당뇨병,2형%강당치료
Homocyteine%Diabetes mellitus, type 2% Hypoglycemic treatment
目的 探讨2型糖尿病(T2DM)患者不同血糖状态及降血糖治疗对血浆同型半胱氨酸(Hey)水平的影响.方法 对225例无明确并发症和合并症的T2DM患者,分别测定FPG、2hPG、血脂、血浆Hey.其中病程3个月内患者43例,进行药物等综合降血糖治疗3个月后再检测以上指标.统计分析血糖控制水平及随访前后糖脂指标变化和Hcy的关系.结果 血糖控制良好的患者血浆Hcy水平较血糖控制差的显著降低(14.10±3.92 vs 15.44±4.28,P<0.05);新诊断的患者治疗后血浆Hcy水平也较治疗前显著降低(14.18士2.26"US 15.25土2.41,P<0.01),血糖控制较好的患者血浆Hcy水平仍较正常人偏高.相关分析显示,血浆Hcy水平主要与FPG和HbA1C正相关(分别r=0.193,0.274,P<0.01).结论 糖尿病患者的血浆Hcy水平升高,良好控制血糖,可以降低血浆Hcy浓度.
目的 探討2型糖尿病(T2DM)患者不同血糖狀態及降血糖治療對血漿同型半胱氨痠(Hey)水平的影響.方法 對225例無明確併髮癥和閤併癥的T2DM患者,分彆測定FPG、2hPG、血脂、血漿Hey.其中病程3箇月內患者43例,進行藥物等綜閤降血糖治療3箇月後再檢測以上指標.統計分析血糖控製水平及隨訪前後糖脂指標變化和Hcy的關繫.結果 血糖控製良好的患者血漿Hcy水平較血糖控製差的顯著降低(14.10±3.92 vs 15.44±4.28,P<0.05);新診斷的患者治療後血漿Hcy水平也較治療前顯著降低(14.18士2.26"US 15.25土2.41,P<0.01),血糖控製較好的患者血漿Hcy水平仍較正常人偏高.相關分析顯示,血漿Hcy水平主要與FPG和HbA1C正相關(分彆r=0.193,0.274,P<0.01).結論 糖尿病患者的血漿Hcy水平升高,良好控製血糖,可以降低血漿Hcy濃度.
목적 탐토2형당뇨병(T2DM)환자불동혈당상태급강혈당치료대혈장동형반광안산(Hey)수평적영향.방법 대225례무명학병발증화합병증적T2DM환자,분별측정FPG、2hPG、혈지、혈장Hey.기중병정3개월내환자43례,진행약물등종합강혈당치료3개월후재검측이상지표.통계분석혈당공제수평급수방전후당지지표변화화Hcy적관계.결과 혈당공제량호적환자혈장Hcy수평교혈당공제차적현저강저(14.10±3.92 vs 15.44±4.28,P<0.05);신진단적환자치료후혈장Hcy수평야교치료전현저강저(14.18사2.26"US 15.25토2.41,P<0.01),혈당공제교호적환자혈장Hcy수평잉교정상인편고.상관분석현시,혈장Hcy수평주요여FPG화HbA1C정상관(분별r=0.193,0.274,P<0.01).결론 당뇨병환자적혈장Hcy수평승고,량호공제혈당,가이강저혈장Hcy농도.
Objective To study the effect of lowering blood glucose and lipids on plasma homocyteine concentration. Method 225 type 2 diabetic patients without definite diabetic complications received the assays of blood glucose, lipids and Hcy. They were divided into two groups: HbA1c>7% and ≤7% group. The 43 of 225 cases with diabetic course shorter than 3 months were re-evaluated by above parameters after 3 months of hypoglycemic treatment to observe the relationship of blood glucose and lipids control with plasma homocyteine concentration. Result Plasma homocyteine concentration was significant lower in HbA1c≤7% group than in HbA1c>7% group (14.10±3.92 vs 15.44±4.28, P<0.05). After 3 months hypoglycemic treatment the Hcy concentration was significantly decreased as compared with pretreatment (14.18±2.26 vs 15.25±2.41, P<0.001). Hcy was related to FPG and HbA1c. Conclusion The plasma homocyteine concentration is increased in diabetic patients versus healthy control. The plasma homocyteine is associated with blood glucose control.
