中华核医学与分子影像杂志
中華覈醫學與分子影像雜誌
중화핵의학여분자영상잡지
Chinese Journal of Nuclear Medicine and Molecular Imaging
2012年
2期
134-137
,共4页
宁艳丽%楼岑%黄中柯%史国华%陈东方%牟达
寧豔麗%樓岑%黃中柯%史國華%陳東方%牟達
저염려%루잠%황중가%사국화%진동방%모체
鼻咽肿瘤%放射性核素显像%符合线路%脱氧葡萄糖
鼻嚥腫瘤%放射性覈素顯像%符閤線路%脫氧葡萄糖
비인종류%방사성핵소현상%부합선로%탈양포도당
Nasopharyngeal neoplasms%Radionuclide imaging%Coincidence%Deoxyglucose
目的 探讨18F-FDG符合线路显像在鼻咽癌诊断中的价值.方法 回顾性分析45例首发鼻咽癌患者资料,均经病理检查证实,治疗前行18F-FDG符合线路显像,计算鼻咽部病灶的放射性计数与全小脑放射性平均计数比(即T/NT)值及肿瘤体积.采用配对x2检验比较18F-FDG符合线路显像与EB病毒相关抗体检测方法阳性率差异;对T/NT值与肿瘤体积行Pearson相关分析;使用ROC曲线确定T/NT值及肿瘤体积的最佳界值;并采用t检验和秩和检验对比分析不同分组方法组间T/NT值及肿瘤体积的差异.结果 18F-FDG符合线路显像阳性率为97.78% (44/45),EB病毒相关抗体总阳性率为95.56% (43/45),两者差异无统计学意义(x2=1.33,P>0.05).鼻咽部原发病灶T/NT值为2.439±1.119,肿瘤体积为(7.311 ±8.280) cm3,两者呈正相关(r=0.463,P<0.05).ROC曲线确定T/NT值的最佳界值为2.396,肿瘤体积的最佳界值为7.348 cm3.首发症状有无涕血组间、有无面部麻木组间及各病理类型组间T/NT值差异均有统计学意义(2.847±1.254与2.082±0.863、2.855±1.261与2.134±0.913、2.266±0.997与2.971±1.351,t=- 2.409、-2.225和-2.018,P均<0.05);首发症状有无面部麻木组间肿瘤体积差异有统计学意义(t=-2.684,P<0.05).按临床分期及T分期分组,组间T/NT值及肿瘤体积差异均无统计学意义(临床分期H=5.895和1.855,P均>0.05,T分期H=4.756和0.270,P均>0.05).结论 18F-FDG符合线路显像诊断鼻咽癌有一定价值,半定量指标T/NT值与肿瘤体积有较好的相关性,T/NT界值的确定需长期大样本研究进一步验证.
目的 探討18F-FDG符閤線路顯像在鼻嚥癌診斷中的價值.方法 迴顧性分析45例首髮鼻嚥癌患者資料,均經病理檢查證實,治療前行18F-FDG符閤線路顯像,計算鼻嚥部病竈的放射性計數與全小腦放射性平均計數比(即T/NT)值及腫瘤體積.採用配對x2檢驗比較18F-FDG符閤線路顯像與EB病毒相關抗體檢測方法暘性率差異;對T/NT值與腫瘤體積行Pearson相關分析;使用ROC麯線確定T/NT值及腫瘤體積的最佳界值;併採用t檢驗和秩和檢驗對比分析不同分組方法組間T/NT值及腫瘤體積的差異.結果 18F-FDG符閤線路顯像暘性率為97.78% (44/45),EB病毒相關抗體總暘性率為95.56% (43/45),兩者差異無統計學意義(x2=1.33,P>0.05).鼻嚥部原髮病竈T/NT值為2.439±1.119,腫瘤體積為(7.311 ±8.280) cm3,兩者呈正相關(r=0.463,P<0.05).ROC麯線確定T/NT值的最佳界值為2.396,腫瘤體積的最佳界值為7.348 cm3.首髮癥狀有無涕血組間、有無麵部痳木組間及各病理類型組間T/NT值差異均有統計學意義(2.847±1.254與2.082±0.863、2.855±1.261與2.134±0.913、2.266±0.997與2.971±1.351,t=- 2.409、-2.225和-2.018,P均<0.05);首髮癥狀有無麵部痳木組間腫瘤體積差異有統計學意義(t=-2.684,P<0.05).按臨床分期及T分期分組,組間T/NT值及腫瘤體積差異均無統計學意義(臨床分期H=5.895和1.855,P均>0.05,T分期H=4.756和0.270,P均>0.05).結論 18F-FDG符閤線路顯像診斷鼻嚥癌有一定價值,半定量指標T/NT值與腫瘤體積有較好的相關性,T/NT界值的確定需長期大樣本研究進一步驗證.
목적 탐토18F-FDG부합선로현상재비인암진단중적개치.방법 회고성분석45례수발비인암환자자료,균경병리검사증실,치료전행18F-FDG부합선로현상,계산비인부병조적방사성계수여전소뇌방사성평균계수비(즉T/NT)치급종류체적.채용배대x2검험비교18F-FDG부합선로현상여EB병독상관항체검측방법양성솔차이;대T/NT치여종류체적행Pearson상관분석;사용ROC곡선학정T/NT치급종류체적적최가계치;병채용t검험화질화검험대비분석불동분조방법조간T/NT치급종류체적적차이.결과 18F-FDG부합선로현상양성솔위97.78% (44/45),EB병독상관항체총양성솔위95.56% (43/45),량자차이무통계학의의(x2=1.33,P>0.05).비인부원발병조T/NT치위2.439±1.119,종류체적위(7.311 ±8.280) cm3,량자정정상관(r=0.463,P<0.05).ROC곡선학정T/NT치적최가계치위2.396,종류체적적최가계치위7.348 cm3.수발증상유무체혈조간、유무면부마목조간급각병리류형조간T/NT치차이균유통계학의의(2.847±1.254여2.082±0.863、2.855±1.261여2.134±0.913、2.266±0.997여2.971±1.351,t=- 2.409、-2.225화-2.018,P균<0.05);수발증상유무면부마목조간종류체적차이유통계학의의(t=-2.684,P<0.05).안림상분기급T분기분조,조간T/NT치급종류체적차이균무통계학의의(림상분기H=5.895화1.855,P균>0.05,T분기H=4.756화0.270,P균>0.05).결론 18F-FDG부합선로현상진단비인암유일정개치,반정량지표T/NT치여종류체적유교호적상관성,T/NT계치적학정수장기대양본연구진일보험증.
Objective To investigate the value of 18F-FDG coincidence imaging for diagnosis of nasopharyngeal carcinoma.Methods A total of 45 patients with nasopharyngeal carcinoma (33 males and 12 females,average age (55.56 ± 13.50) years),who underwent 18F-FDG coincidence imaging before treatment,were studied retrospectively.The images of 18F-FDG coincidence imaging (GE Millennium VG SPECT) and MRI were analyzed.The radioactivity ratio of the accumulated regions to cerebellum (T/NT)was calculated by ROI technique.The volume of nasopharyngeal carcinoma was recorded by MRI.The positive rates of 18F-FDG coincidence imaging and EB virus-related antibody measurements were compared by paired x2 test.The correlation between T/NT ratios and tumor volumes were tested by Pearson correlation,and then ROC curves were established.The T/NT ratios and tumor volumes of different groups ( different first symptoms,clinical stages,T stages,pathological classification and outcomes,with or without lymph node enlargement) were compared by t-test and rank sum test.Results The positive rate of 18F-FDG coincidence imaging was 97.78% (44/45),and the positive rate of EB virus-related antibody measurement was 95.56% (43/45,x2 =1.33,P>0.05).The T/NT ratio (2.439 ±1.119) and tumor volume ((7.311 ± 8.280) cm3) of primary lesions had a positive correlation(r =0.463,P < 0.05).The cut-off values of T/NT ratio and the tumor volume were 2.396 and 7.348 cm3,respectively,by ROC curves.T/NT ratios in groups with or without first symptom of epistaxis (2.847 ± 1.254 vs 2.082 ± 0.863,t =- 2.409) and groups with or without facial numbness (2.855 ± 1.261 vs 2.134 ± 0.913,t =-2.225 ) were both significantly different (both P < 0.05).T/NT ratios of differentiated and undifferentiated cancer were 2.266 ± 0.997 and 2.971 ± 1.351,respectively ( t =- 2.018,P < 0.05 ).There was a significant difference of tumor volumes between groups with or without facial numbness ( t =- 2.684,P < 0.05 ).T/NT ratios and tumor volumes between groups of different clinical stages (H =5.895 and 1.855,both P > 0.05) and T stages (H =4.756 and 0.270,both P > 0.05 ) were significantly different.Conclusions 18 F-FDG coincidence imaging plays a role in the diagnosis of nasopharyngeal carcinoma.The cut-off value of T/NT ratio is helpful for the prognosis prediction of nasopharyngeal carcinoma.