CAJ | 학술논문

[目的]合成具有pH敏感、缓释特性的壳聚糖-地塞米松前药,通过透析法制备前药胶束纳米粒子.[方法]通过缩合反应将壳聚糖与地塞米松通过腙键共价连接,制备壳聚糖负载的地塞米松前药,并通过核磁氢谱对其进行结构表征；通过透析法制备壳聚糖-地塞米松胶束纳米粒子,并用动态光散射仪和透射电镜考察粒子的粒径和形貌；考察壳聚糖-地塞米松pH敏感型纳米胶束前药在不同pH缓冲液中的释药特性.[结果]合成的前药鉴定为预期产物.通过透析法制得的前药纳米粒子粒径在100～250 nm之间；该前药在pH=5.8条件下的释放速率要快于pH=7.4条件下的释放速率,具有pH敏感性.[结论]成功合成了壳聚糖-地塞米松前药,通过透析法成功制备了前药胶束纳米粒子,该前药具有在低pH条件下释放较快的pH敏感性.
[목적]합성구유pH민감、완석특성적각취당-지새미송전약,통과투석법제비전약효속납미입자.[방법]통과축합반응장각취당여지새미송통과종건공개련접,제비각취당부재적지새미송전약,병통과핵자경보대기진행결구표정；통과투석법제비각취당-지새미송효속납미입자,병용동태광산사의화투사전경고찰입자적립경화형모；고찰각취당-지새미송pH민감형납미효속전약재불동pH완충액중적석약특성.[결과]합성적전약감정위예기산물.통과투석법제득적전약납미입자립경재100～250 nm지간；해전약재pH=5.8조건하적석방속솔요쾌우pH=7.4조건하적석방속솔,구유pH민감성.[결론]성공합성료각취당-지새미송전약,통과투석법성공제비료전약효속납미입자,해전약구유재저pH조건하석방교쾌적pH민감성.
[Objective]To synthesise the prodrug of chitosan-dexamethasone with pH sensitive release property.[Methods]The chitosan-dexamethasone prodrug was prepared by covalently linking via hydrazone bonds,and the structure of the prodrug was verified by 1H-NMR.The nanoprodrug was prepared by dialyse method,and the size and morphology were observed by dynamic light scattering and transmission electron microscope.The drug release in different pH of the prodrug was evaluated.[Results]The prodrug was synthesized and confirmed as expected.The size of the prodrug nanoparticle was about 100 ～ 250 nm,and the prodrug realeased faster in pH 5.8 than in pH 7.4 PBS solution.Conclsion The pH sensitve chitosan-dexamethasone prodrug is synthesized successfully,which has potential application in the rheumatoid arthritis treatment.