中国医师杂志
中國醫師雜誌
중국의사잡지
JOURNAL OF CHINESE PHYSICIAN
2010年
5期
600-602
,共3页
肾肿瘤/代谢%腺癌,透明细胞/代谢%缺氧诱导因子1,α亚基/代谢%微管相关蛋白质类/代谢
腎腫瘤/代謝%腺癌,透明細胞/代謝%缺氧誘導因子1,α亞基/代謝%微管相關蛋白質類/代謝
신종류/대사%선암,투명세포/대사%결양유도인자1,α아기/대사%미관상관단백질류/대사
Kidney neoplasms/ME%Adenocarcinoma,clear cell/ME%Hypoxia-inducible factor1,alpha Subunit/ME%Microrubule-associated proteins/ME
目的 探讨肾透明细胞癌组织中缺氧诱导因子-1α(HIF-1α)和存活素(survivin)的表达、与Robson分期关系及两者的相互关系.方法 采用免疫组化法检测32例肾透明细胞癌及10例正常肾脏组织中HIF-1α和survivin的表达.结果 HIF-1α和survivin在肾透明细胞癌中的表达(分别为0.037±0.0182,0.093±0.0384)较正常组织(分别为0.008±0.0055,0.014±0.0059)明显升高(P<0.05);按Robson分期Ⅲ,Ⅳ期者(0.053±0.0179,0.137±0.0291)较Ⅰ,Ⅱ期者(0.029±0.0117,0.070 ±0.0154)明显增高(P<0.05);二者表达呈正相关(r=0.655,P<0.05).结论 肾透明细胞癌中HIF-1α和survivin表达增加且与分期相关;二者表达呈正相关(r=1.000.0.655,P<0.05).
目的 探討腎透明細胞癌組織中缺氧誘導因子-1α(HIF-1α)和存活素(survivin)的錶達、與Robson分期關繫及兩者的相互關繫.方法 採用免疫組化法檢測32例腎透明細胞癌及10例正常腎髒組織中HIF-1α和survivin的錶達.結果 HIF-1α和survivin在腎透明細胞癌中的錶達(分彆為0.037±0.0182,0.093±0.0384)較正常組織(分彆為0.008±0.0055,0.014±0.0059)明顯升高(P<0.05);按Robson分期Ⅲ,Ⅳ期者(0.053±0.0179,0.137±0.0291)較Ⅰ,Ⅱ期者(0.029±0.0117,0.070 ±0.0154)明顯增高(P<0.05);二者錶達呈正相關(r=0.655,P<0.05).結論 腎透明細胞癌中HIF-1α和survivin錶達增加且與分期相關;二者錶達呈正相關(r=1.000.0.655,P<0.05).
목적 탐토신투명세포암조직중결양유도인자-1α(HIF-1α)화존활소(survivin)적표체、여Robson분기관계급량자적상호관계.방법 채용면역조화법검측32례신투명세포암급10례정상신장조직중HIF-1α화survivin적표체.결과 HIF-1α화survivin재신투명세포암중적표체(분별위0.037±0.0182,0.093±0.0384)교정상조직(분별위0.008±0.0055,0.014±0.0059)명현승고(P<0.05);안Robson분기Ⅲ,Ⅳ기자(0.053±0.0179,0.137±0.0291)교Ⅰ,Ⅱ기자(0.029±0.0117,0.070 ±0.0154)명현증고(P<0.05);이자표체정정상관(r=0.655,P<0.05).결론 신투명세포암중HIF-1α화survivin표체증가차여분기상관;이자표체정정상관(r=1.000.0.655,P<0.05).
Objective To investigate the expression of HIF-1α and survivin in renal clear cell carcinoma (RCC) and normal renal tissue ( NRT) and explore the correlation between HIF-1α and survivin expression. Method SABC immunohistochemical staining was performed to detect the expression in 32 cases of RCC and 10 cases of NRT.Results The level of positive HIF-1α immunostaining in RCC(0. 037 ±0. 0182,0. 093 ±0. 0384,respectively) was higher than NRT(0. 008 ±0.0055,0. 014 ±0. 0059, respectively) ( P<0. 05). The level of positive survivin immunostaining in RCC(0. 053 ±0.0179,0. 137 ±0.0291) was higher than NRT( P<0. 05). The expression of HIF-1α and survivin had positive relationship with clinical stage in RCC(0. 029 ±0. 0117,0.070±0.0154)( P <0.05). The expression of HIF-la had relation with survivin in RCC( r = 0. 655, P < 0. 05).Conclusion The expression of HIF-1α was strongly positive correlated with survivin ( r = 1.000,0. 655, P <0. 05).
