中国全科医学
中國全科醫學
중국전과의학
CHINESE GENERAL PRACTICE
2010年
8期
824-826
,共3页
消化性溃疡出血%非甾体抗炎药%幽门螺杆菌%危险因素
消化性潰瘍齣血%非甾體抗炎藥%幽門螺桿菌%危險因素
소화성궤양출혈%비치체항염약%유문라간균%위험인소
Peptic ulcer hemorrhage%Non-steroidal anti-inflammatory drugs%Helicobacter pylori%Risk factors
目的 探讨服用非甾体抗炎药(NSAIDs)和幽门螺杆菌(H.pylori)感染与消化性溃疡并发出血的关系.方法 收集2007年1月-2009年7月在新疆医科大学第一临床医学院消化内科收治的消化性溃疡患者205例,均行内镜检查确诊(除外复合溃疡),并行病理学检查排除胃癌.对消化性溃疡并发出血的危险因素行单因素和多因素分析.结果 205例消化性溃疡患者中,男150例(73.2%),女55例(26.8%);中位年龄49(12～88)岁;并发出血87例(42.4%).在单因素分析中,出血组与未出血组患者中年龄≥60岁者、既往有消化道出血史者、心脑血管病史者、有多个溃疡者所占比例间差异均有统计学意义(P＜0.01);进一步行Logistic逐步回归分析,发现年龄≥60岁、有消化性溃疡史、消化道出血史、心脑血管病史和单纯H.pylori感染、单纯服用NSAIDs、H.pylori感染同时服用NSAIDs为消化性溃疡并发出血的危险因素.结论 H.pylori感染并未增加溃疡并发出血的危险性,但与服用NSAIDs、年龄≥60岁、消化性溃疡或出血史、心脑血管病史等因素联合可增加溃疡并发出血的危险性.
目的 探討服用非甾體抗炎藥(NSAIDs)和幽門螺桿菌(H.pylori)感染與消化性潰瘍併髮齣血的關繫.方法 收集2007年1月-2009年7月在新疆醫科大學第一臨床醫學院消化內科收治的消化性潰瘍患者205例,均行內鏡檢查確診(除外複閤潰瘍),併行病理學檢查排除胃癌.對消化性潰瘍併髮齣血的危險因素行單因素和多因素分析.結果 205例消化性潰瘍患者中,男150例(73.2%),女55例(26.8%);中位年齡49(12～88)歲;併髮齣血87例(42.4%).在單因素分析中,齣血組與未齣血組患者中年齡≥60歲者、既往有消化道齣血史者、心腦血管病史者、有多箇潰瘍者所佔比例間差異均有統計學意義(P＜0.01);進一步行Logistic逐步迴歸分析,髮現年齡≥60歲、有消化性潰瘍史、消化道齣血史、心腦血管病史和單純H.pylori感染、單純服用NSAIDs、H.pylori感染同時服用NSAIDs為消化性潰瘍併髮齣血的危險因素.結論 H.pylori感染併未增加潰瘍併髮齣血的危險性,但與服用NSAIDs、年齡≥60歲、消化性潰瘍或齣血史、心腦血管病史等因素聯閤可增加潰瘍併髮齣血的危險性.
목적 탐토복용비치체항염약(NSAIDs)화유문라간균(H.pylori)감염여소화성궤양병발출혈적관계.방법 수집2007년1월-2009년7월재신강의과대학제일림상의학원소화내과수치적소화성궤양환자205례,균행내경검사학진(제외복합궤양),병행병이학검사배제위암.대소화성궤양병발출혈적위험인소행단인소화다인소분석.결과 205례소화성궤양환자중,남150례(73.2%),녀55례(26.8%);중위년령49(12～88)세;병발출혈87례(42.4%).재단인소분석중,출혈조여미출혈조환자중년령≥60세자、기왕유소화도출혈사자、심뇌혈관병사자、유다개궤양자소점비례간차이균유통계학의의(P＜0.01);진일보행Logistic축보회귀분석,발현년령≥60세、유소화성궤양사、소화도출혈사、심뇌혈관병사화단순H.pylori감염、단순복용NSAIDs、H.pylori감염동시복용NSAIDs위소화성궤양병발출혈적위험인소.결론 H.pylori감염병미증가궤양병발출혈적위험성,단여복용NSAIDs、년령≥60세、소화성궤양혹출혈사、심뇌혈관병사등인소연합가증가궤양병발출혈적위험성.
Objective To analyze the relationship between non-steroidal anti-inflammatory drugs (NSAIDs) and Helicobacter pylori(H.pylori)in Bleeding peptic ulcer(BPU).Methods All peptic ulcers (PU) inpatients were diagnosed by endoscopy in our hospital from January 2007 to July 2009 were collected(except complex ulcer).Gastric carcinoma was excluded by pathologic examination.The risk factors of bleeding in PU patients were analyzed by single factor and multifactor.Results Of the 205 PU cases,including 150 (73.2%) male and 55 (26.8%) female patients.The median age was 49 (12～88) years,bleeding occurred in 87 (42.4%) cases of PU.Univariate analysis identified 5 statistically significant variables,including aged 60 years or older,the history of BPU and cardio-cerebral-vascular diseases,ulcer number and NSAIDs use.Logistic stepwise regression analysis showed that aged 60 years or older,the history of PU or BPU,the history of cardio-cerebral-vascular diseases,H.pylori infection alone,NSAIDs consumption alone and combined H.pylori infection and NSAIDs use were independent risk factors of BPU.Conclusion H.pylori infection was not a risk factor for BPU,but the combination of H.pylori infection and NSAID use,aged 60 years or older,the history of PU or BPU,the history of cardio-cerebral-vascular diseases were associated with an increased risk of BPU.
