CAJ | 학술논문

以往认为寻常型天疱疮仅由致病性抗体作用导致的一类自身免疫性皮肤黏膜疾病.但近年来其发病机制不断被揭示,凋亡在疾病中的作用亦越来越明确,如角质形成细胞经抗体直接作用可产生凋亡现象;棘层松解后形成的细胞间连接丧失可触发失巢凋亡.松解凋亡的提出进一步阐明棘层松解和细胞凋亡之间的关联性,也证明寻常型天疱疮的凋亡与传统的凋亡现象不同,具有其特殊性,对寻找疾病治疗的新靶点具有重要意义.
이왕인위심상형천포창부유치병성항체작용도치적일류자신면역성피부점막질병.단근년래기발병궤제불단피게시,조망재질병중적작용역월래월명학,여각질형성세포경항체직접작용가산생조망현상;극층송해후형성적세포간련접상실가촉발실소조망.송해조망적제출진일보천명극층송해화세포조망지간적관련성,야증명심상형천포창적조망여전통적조망현상불동,구유기특수성,대심조질병치료적신파점구유중요의의.
Pemphigus vulgaris was previously regarded as an pathogenic antibody-mediated autoimmune mucocutaneous disease. However, with the increase in knowledge about the pathogenesis of this entity, the roles of apoptosis in the development of pemphigus vulgaris have become more and more clear. For example, the apoptosis of keratinocytes can be induced by direct action of antibodies, and anoikis can be triggered by loss of cellular linkage following acantholysis. The hypothesis of apoptolysis further clarifies the correlation between apoptosis and acantholysis, and confirms that the apoptosis in pemphigus vulgaris is a unique paradigm of cell damage and detachment which should be distinguished from other classic known forms of cell death. These findings will facilitate the search of new targets for treatment of pemphigus vulgaris.