CAJ | 학술논문

结核分枝杆菌(MTB)全基因序列测定的完成和比较基因组学的发展,使得对MTB毒力和致病机制的认识不断深入,近年发现RDI区在MTB的致病机制中充当重要角色,而RDI区编码的ESX-1蛋白组成的分泌转运系统与MTB的毒力关系密切.此文主要从MTB RD1/ESX-1蛋白分泌转运系统对ESAT-6/CFP-10分泌输出的影响,探讨其与MTB的毒力和致病机制的关系.
결핵분지간균(MTB)전기인서렬측정적완성화비교기인조학적발전,사득대MTB독력화치병궤제적인식불단심입,근년발현RDI구재MTB적치병궤제중충당중요각색,이RDI구편마적ESX-1단백조성적분비전운계통여MTB적독력관계밀절.차문주요종MTB RD1/ESX-1단백분비전운계통대ESAT-6/CFP-10분비수출적영향,탐토기여MTB적독력화치병궤제적관계.
The availability on the complete genome sequence of M.tuberculosis(MTB)and the development of the comparative genomics,have led to important advances in understanding the pathogenesis of tuberculosis.An important role with RD1 of genome in MIB pathogenesis has been demonstrated.and the secretion-transport system which is composed of ESX-1 proteins encoded by MTB RD1 locus is in close relation with the virulence of MTB.THis text mainly describes the influence of the secretion-transport system of MTB RD1/ESX-1 on the secretion and export of ESAT-6/CFP-10,so as to investigate the relation between the secretion-transport system and the virulence and pathogenesis of MTB.