中国地方病学杂志
中國地方病學雜誌
중국지방병학잡지
CHINESE JOURNAL OF ENDEMIOLOGY
2012年
1期
74-77
,共4页
方铭喜%翟迎九%薛莉%方琦%吴金芳%田国力%吴奕华%高静%蔡贤华%胡秀华
方銘喜%翟迎九%薛莉%方琦%吳金芳%田國力%吳奕華%高靜%蔡賢華%鬍秀華
방명희%적영구%설리%방기%오금방%전국력%오혁화%고정%채현화%호수화
孕妇%婴儿,新生%碘%促甲状腺素
孕婦%嬰兒,新生%碘%促甲狀腺素
잉부%영인,신생%전%촉갑상선소
Pregnant women%Infant,newborn%Iodine%Thyrotropin
目的 调查上海市浦东新区周浦和康桥地区(简称周康地区)孕妇的碘营养状况,新生儿足跟血促甲状腺激素(TSH)水平及其与母体孕期尿碘水平之间的关系.方法 于2009年4月至2010年11月,选择上海市周康地区孕早、中、晚期妇女各200例,哺乳期妇女193例,生育期非孕妇女(简称育龄期妇女)200例,同期新生儿200例作为观察对象.采集各期妇女随意1次尿样,用砷铈催化法检测尿碘,同时采集新生儿出生后72 h的足跟血,用时间分辨荧光免疫法(TRFIA)测定TSH.结果 600例孕妇的尿碘中位数为161.35 μg/L,其中孕晚期妇女尿碘中位数(126.35 μg/L)明显低于孕早、中期,哺乳期及育龄期妇女(178.80、180.50、167.90、163.40μg/L,P均＜0.05)；孕晚期妇女尿碘＜150 μg/L的比例[57.5％(115/200)]明显高于孕早、中期,哺乳期,育龄期妇女[39.0％(78/200)、39.5％(79/200)、16.6％(32/193)、23.0％(46/200),P均＜0.05].孕早、中、晚期妇女尿碘≥300 μg/L的比例[9.0％(18/200)、8.0％(16/200)、5.0％ (10/200)]明显低于哺乳期、育龄期妇女[20.2％(39/193)、20.5％(41/200),P均＜0.05].200例新生儿足跟血TSH水平为(2.92±1.83)mU/L,范围为0.01～9.76 mU/L,TSH＞5 mU/L的比例为11.0％(22/200),超过世界卫生组织(WHO)碘营养适宜标准(＜3％).结论 上海市浦东新区周康地区孕妇总体碘营养水平处在适宜范围,但孕晚期妇女存在轻度碘营养不足,而该区新生儿有碘营养缺乏的可能.应加强对孕妇碘营养的监测,科学补碘.
目的 調查上海市浦東新區週浦和康橋地區(簡稱週康地區)孕婦的碘營養狀況,新生兒足跟血促甲狀腺激素(TSH)水平及其與母體孕期尿碘水平之間的關繫.方法 于2009年4月至2010年11月,選擇上海市週康地區孕早、中、晚期婦女各200例,哺乳期婦女193例,生育期非孕婦女(簡稱育齡期婦女)200例,同期新生兒200例作為觀察對象.採集各期婦女隨意1次尿樣,用砷鈰催化法檢測尿碘,同時採集新生兒齣生後72 h的足跟血,用時間分辨熒光免疫法(TRFIA)測定TSH.結果 600例孕婦的尿碘中位數為161.35 μg/L,其中孕晚期婦女尿碘中位數(126.35 μg/L)明顯低于孕早、中期,哺乳期及育齡期婦女(178.80、180.50、167.90、163.40μg/L,P均＜0.05)；孕晚期婦女尿碘＜150 μg/L的比例[57.5％(115/200)]明顯高于孕早、中期,哺乳期,育齡期婦女[39.0％(78/200)、39.5％(79/200)、16.6％(32/193)、23.0％(46/200),P均＜0.05].孕早、中、晚期婦女尿碘≥300 μg/L的比例[9.0％(18/200)、8.0％(16/200)、5.0％ (10/200)]明顯低于哺乳期、育齡期婦女[20.2％(39/193)、20.5％(41/200),P均＜0.05].200例新生兒足跟血TSH水平為(2.92±1.83)mU/L,範圍為0.01～9.76 mU/L,TSH＞5 mU/L的比例為11.0％(22/200),超過世界衛生組織(WHO)碘營養適宜標準(＜3％).結論 上海市浦東新區週康地區孕婦總體碘營養水平處在適宜範圍,但孕晚期婦女存在輕度碘營養不足,而該區新生兒有碘營養缺乏的可能.應加彊對孕婦碘營養的鑑測,科學補碘.
목적 조사상해시포동신구주포화강교지구(간칭주강지구)잉부적전영양상황,신생인족근혈촉갑상선격소(TSH)수평급기여모체잉기뇨전수평지간적관계.방법 우2009년4월지2010년11월,선택상해시주강지구잉조、중、만기부녀각200례,포유기부녀193례,생육기비잉부녀(간칭육령기부녀)200례,동기신생인200례작위관찰대상.채집각기부녀수의1차뇨양,용신시최화법검측뇨전,동시채집신생인출생후72 h적족근혈,용시간분변형광면역법(TRFIA)측정TSH.결과 600례잉부적뇨전중위수위161.35 μg/L,기중잉만기부녀뇨전중위수(126.35 μg/L)명현저우잉조、중기,포유기급육령기부녀(178.80、180.50、167.90、163.40μg/L,P균＜0.05)；잉만기부녀뇨전＜150 μg/L적비례[57.5％(115/200)]명현고우잉조、중기,포유기,육령기부녀[39.0％(78/200)、39.5％(79/200)、16.6％(32/193)、23.0％(46/200),P균＜0.05].잉조、중、만기부녀뇨전≥300 μg/L적비례[9.0％(18/200)、8.0％(16/200)、5.0％ (10/200)]명현저우포유기、육령기부녀[20.2％(39/193)、20.5％(41/200),P균＜0.05].200례신생인족근혈TSH수평위(2.92±1.83)mU/L,범위위0.01～9.76 mU/L,TSH＞5 mU/L적비례위11.0％(22/200),초과세계위생조직(WHO)전영양괄의표준(＜3％).결론 상해시포동신구주강지구잉부총체전영양수평처재괄의범위,단잉만기부녀존재경도전영양불족,이해구신생인유전영양결핍적가능.응가강대잉부전영양적감측,과학보전.
Objective To investigate the iodine nutritional status of pregnant women,newborn heel blood thyroid stimulating hormone(TSH) level and their relationship with urinary iodine(UI) level during pregnancy in Zhoupu and Kangqiao districts of Pudong New Area of Shanghai.Methods A total of 993 urinary samples(the first,second and third trimesters of pregnancy were 200 people,respectively),breast feeding(193 people) and non-pregnant women (200 people) in Zhoupu and Kangqiao districts of Pudong New area were collected from Apr 2009 to Dec 2010.Two hundred copies of neonatal heel blood samples were collected.Median of UI was measured by arsenic-cerium catalysis.TSH in neonatal heel blood was analyzed 72 h after birth by time resolved fluoroisnmunoassay(TRFIA).Results Median UI of all pregnant women was 161.35 μg/L,and that in third trimesters of pregnancy( 126.35 μg/L) was lower than that of the first,the second,the breast feeding and non-pregnant women (178.80,180.50,167.90,163.40 μg/L,all P＜ 0.05).The percentage of UI level less than 150 μg/L in the third trimester[57.5％(115/200) ] was higher than that of the first[39.0％(78/200) ],the second[39.5％(79/200) ],the breast feeding [ 16.6％ (32/193) ] and non-pregnant women [ 23.0％ (46/200) ],respectively (all P ＜ 0.05).The percentage of UI level higher than 300 μg/L in the first [9.0％(18/200)],the second[8.0％(16/200) ] and the third trimester [ 5.0％ ( 10/200 ) ] of pregnancy was lower than that of the breast feeding [ 20.2％ (39/193) ] and nonpregnant [20.5％(41/200) ] women,respectively(all P ＜ 0.05).The level of neonatal heel blood TSH was(2.92 ± 1.83)mU/L,the range was 0.01 - 9.76 mU/L,11.0％(22/200) of the neonates heel blood TSH level(5 mU/L)exceeded the ratio of World Health Organization (WHO) standard ( ＜ 3％ ) suitable for iodine nutrition.Conclusions The overall level of iodine nutrition among pregnant women in Zhoupu and Kangqiao districts of Pudong New Area of Shanghai is in the appropriate range,but the pregnant women in the third trimester is in mild iodine deficiencies,and the neonates in these districts may be prone to iodine deficiency.Monitoring of iodine nutrition of pregnant women should be strengthened and iodine supplementation should be done scientifically.
