CAJ | 학술논문

目的探讨还原型谷胱甘肽(GSH)对严重延迟复苏烧伤患者肝功能损害的影响.方法选择40例严重延迟复苏烧伤患者,随机分为两组,治疗组20例静脉滴注GSH;对照组20例给予能量合剂,均连续治疗7～14 d.于治疗前及治疗后7 d、14 d抽取患者静脉血,检测血清丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)、r-谷氨酰转肽酶(r-GT)、碱性磷酸酶(ALP)、总胆红素(TBIL)及直接胆红素(DBIL),并进行对比分析.结果治疗组治疗后7 d各指标即显著下降,14 d时进一步下降,与治疗前比较差异均有统计学意义(P＜0.05或P＜0.01);对照组治疗后7 d虽较治疗前有所下降,但差异无统计学意义,14 d时各指标均显著下降(P均＜0.05).与对照组14 d时比较,治疗组ALT、AST、7-GT、TBIL、DBIL下降显著(P均＜0.05),而ALP差异无统计学意义.结论早期给予GSH对改善严重延迟复苏烧伤患者肝功能损害的疗效显著.
목적 탐토환원형곡광감태(GSH)대엄중연지복소소상환자간공능손해적영향.방법 선택40례엄중연지복소소상환자,수궤분위량조,치료조20례정맥적주GSH;대조조20례급여능량합제,균련속치료7～14 d.우치료전급치료후7 d、14 d추취환자정맥혈,검측혈청병안산전안매(ALT)、천동안산전안매(AST)、r-곡안선전태매(r-GT)、감성린산매(ALP)、총담홍소(TBIL)급직접담홍소(DBIL),병진행대비분석.결과 치료조치료후7 d각지표즉현저하강,14 d시진일보하강,여치료전비교차이균유통계학의의(P＜0.05혹P＜0.01);대조조치료후7 d수교치료전유소하강,단차이무통계학의의,14 d시각지표균현저하강(P균＜0.05).여대조조14 d시비교,치료조ALT、AST、7-GT、TBIL、DBIL하강현저(P균＜0.05),이ALP차이무통계학의의.결론 조기급여GSH대개선엄중연지복소소상환자간공능손해적료효현저.
Objective To investigate the protective effects of the reduced glutathione(GSH)on hepatic injury after delayed resuscitation in patients with severe burn.Methods Forty severely burned patients with hepatic injury after delayed resuscitation were randomly divided into two groups:treatment group(T,20 cases)and control group(C,20 cases).In the T group,the patients were treated with GSH for 7-14 days,while the patients in the C group were treated with same quantity of "energy mixture" as control.The venous blood sample of each patient of the two groups was collected and examined for the content of alanine aminotransferase(ALT),aspartate aminotransferase(AST),r-glutamyltranspeptidase (r-GT),alkaline phosphatase(ALP),total bilirubin(TBIL),and direct bilirubin(DBIL)before the treatment and 7 days and 14 days after the treatment.Results The contents of the enzymes in the T group were significantly decreasing gradually in all patients after 7 days and 14 days of treatment(P＜0.05 or P＜0.01).In the C group,the enzymes showed a decrease in quantity 7 days after the management but without statistical significance.However,they still showed significant decrease on 14th day with the"energy mixture"treatment(all P＜0.05).After 14 days of the treatment,ALT,AST,r-GT,TBIL and DBIL showed obvious decrease in the T group compared to the C group(all P＜0.05),but there was no significant difference in ALP between the two groups.Conclusion The results of this study indicates that early use of GSH may be beneficial in the management of protecting hepatic injury after delayed resuscitation for severe burn.