CAJ | 학술논문

目的评价电话版常识-记忆-注意测验(TIMCT)在鼻咽癌放疗后患者认知功能检测的应用价值.方法对正常人(30例)和放疗结束3个月、2年、5年的鼻咽癌门诊复查患者(各30例)首先使用以往简易精神状态检查法(MMSE)和修订后的TIMCT面访,以及面访2周后再电话访问(电访)1次.结果不以MMSE得分作为控制变量,全组TIMCT电访与TIMCT面访评分相关性较大,R=0.850;以MMSE得分作为控制变量,全组TIMCT电访与TIMCT面访评分相关性较低,R=0.366;以检测时机为分层因素作TIMCT电话访问与TTMCT面访评分的偏相关分析表明两者仅在正常人和放疗结束3个月者有相关性,放疗结束2年和5年者无相关性(R=0.447、0.970、0.200、0.062).TIMCT电访与TTMCT面访评分差值散点图进一步表明只有当MMSE评分≥28分时电访与面访评分才会一致,但面访与电访都可以反映研究对象认知功能下降的趋势.结论 TIMCT电访与TIMCT面访、MMSE面访可以反映放疗结束后鼻咽癌门诊复查患者认知功能下降的趋势,但TIMCT电访尚须进一步改良才能应用于鼻咽癌放疗结束后认知功能损伤的临床筛查.
목적 평개전화판상식-기억-주의측험(TIMCT)재비인암방료후환자인지공능검측적응용개치.방법 대정상인(30례)화방료결속3개월、2년、5년적비인암문진복사환자(각30례)수선사용이왕간역정신상태검사법(MMSE)화수정후적TIMCT면방,이급면방2주후재전화방문(전방)1차.결과 불이MMSE득분작위공제변량,전조TIMCT전방여TIMCT면방평분상관성교대,R=0.850;이MMSE득분작위공제변량,전조TIMCT전방여TIMCT면방평분상관성교저,R=0.366;이검측시궤위분층인소작TIMCT전화방문여TTMCT면방평분적편상관분석표명량자부재정상인화방료결속3개월자유상관성,방료결속2년화5년자무상관성(R=0.447、0.970、0.200、0.062).TIMCT전방여TTMCT면방평분차치산점도진일보표명지유당MMSE평분≥28분시전방여면방평분재회일치,단면방여전방도가이반영연구대상인지공능하강적추세.결론 TIMCT전방여TIMCT면방、MMSE면방가이반영방료결속후비인암문진복사환자인지공능하강적추세,단TIMCT전방상수진일보개량재능응용우비인암방료결속후인지공능손상적림상사사.
Objective To investigate the telephone information-memory-concentration test (TIMCT) in evaluating the cognitive function of patients with nasopharyngeal carcinoma(NPC)after radiotherapy. Methods The cognitive function were evaluated by TIMCT and mini mental state examination (MMSE) in 2 weeks for 30 normal persons and 90 NPC patients. And the 90 NPC patients were divided into the 3 months, 2 years and 5 years after radiotherapy groups. All patients were carried out firstly face to face interview and telephone interview 1 time after 2 weeks. Results The correlation coefficient of all groups between TIMCT(telephone) and TIMCT (face to face) were bigger (R = 0.850) when MMSE wasn't control variable. And the correlation coefficients between TIMCT (telephone) and TIMCT (face to face) were lower (R = 0.366) when MMSE was control variable. As for examining time was classification factor, TIMCT (telephone) and TIMCT (face to face) were analyzed by partial correlation analysis. Only normal group was correlated with group of 3 months after radiotherapy and group of 2 years after radiotherapy wasn't correlated with group of 5 years after radiotherapy (R = 0.447,0.970,0.200 and 0.062). In addition, the difference plot of TIMCT(telephone) and TIMCT (face to face) indicated that telephone was consistent with face to face interview (MMSE≥28). Both telephone and face to face interview reflected the cognitive function downtrend of rescareh objects. Conclusions TIMCT (telephone), TIMCT(face to face) and MMSE (face to face) can reflect cognitive function downterend of patients with NPC after radiotherapy. But TIMCT(telephone) used in clinical screening cognitive function impairment of patients with NPC after radiotherapy should be improved further.