中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2011年
17期
3-5
,共3页
胰腺炎%抗生素类,抗真菌%预防
胰腺炎%抗生素類,抗真菌%預防
이선염%항생소류,항진균%예방
Pancreatitis%Antibiotics,antifungal%Prevention
目的 探讨应用预防性抗真菌治疗是否可以降低重症急性胰腺炎(SAP)患者真菌感染的发生率及病死率.方法 选择2008年1月至2009年12月收治的40例存在真菌感染高危因素的SAP患者,按随机数字表法分为预防组和对照组,每组20例.对照组应用常规治疗,预防组除常规治疗外,应用氟康唑预防性抗真菌治疗.比较两组住院时间、真菌感染发生时间、真菌感染发生率以及病死率.结果 预防组与对照组比较,住院时间缩短[(40.3±15.4)d比(46.5±18.5)d],真菌感染发生时间较晚[(24.5±14.3)d比(14.5±12.7)d],真菌感染发生率低[15.0%(3/20)比35.O%(7/20)],病死率低[10.0%(2/20)比25.0%(5/20)],差异均有统计学意义(P<0.05).结论 SAP患者预防性抗真菌治疗,缩短住院时间,延缓真菌感染发生时间,降低真菌感染发生率及患者病死率.
目的 探討應用預防性抗真菌治療是否可以降低重癥急性胰腺炎(SAP)患者真菌感染的髮生率及病死率.方法 選擇2008年1月至2009年12月收治的40例存在真菌感染高危因素的SAP患者,按隨機數字錶法分為預防組和對照組,每組20例.對照組應用常規治療,預防組除常規治療外,應用氟康唑預防性抗真菌治療.比較兩組住院時間、真菌感染髮生時間、真菌感染髮生率以及病死率.結果 預防組與對照組比較,住院時間縮短[(40.3±15.4)d比(46.5±18.5)d],真菌感染髮生時間較晚[(24.5±14.3)d比(14.5±12.7)d],真菌感染髮生率低[15.0%(3/20)比35.O%(7/20)],病死率低[10.0%(2/20)比25.0%(5/20)],差異均有統計學意義(P<0.05).結論 SAP患者預防性抗真菌治療,縮短住院時間,延緩真菌感染髮生時間,降低真菌感染髮生率及患者病死率.
목적 탐토응용예방성항진균치료시부가이강저중증급성이선염(SAP)환자진균감염적발생솔급병사솔.방법 선택2008년1월지2009년12월수치적40례존재진균감염고위인소적SAP환자,안수궤수자표법분위예방조화대조조,매조20례.대조조응용상규치료,예방조제상규치료외,응용불강서예방성항진균치료.비교량조주원시간、진균감염발생시간、진균감염발생솔이급병사솔.결과 예방조여대조조비교,주원시간축단[(40.3±15.4)d비(46.5±18.5)d],진균감염발생시간교만[(24.5±14.3)d비(14.5±12.7)d],진균감염발생솔저[15.0%(3/20)비35.O%(7/20)],병사솔저[10.0%(2/20)비25.0%(5/20)],차이균유통계학의의(P<0.05).결론 SAP환자예방성항진균치료,축단주원시간,연완진균감염발생시간,강저진균감염발생솔급환자병사솔.
Objective To investigate whether prophylactic antifungal treatment will reduce the incidence of fungal infection(FI)and the mortality in severe acute pancreatitis(SAP).Methods Forty consecutive patients with SAP admitted from January 2008 to December 2009 were divided into prevention group and control group with 20 cases each by random digits table.The patients in prevention group underwent routine therapy plus intravenous fluconazol as prophylactic antifungal treatment,while routine therapy only in control group.The length of hospital stay,the time when FI occurred,the incidence of FI and mortality were compared with each other.Results Compared with control group,the length of hospital stay wag shorter[(40.3±15.4)d vs.(46.5±18.5)d],the time when FI occurred was slewer[(24.5±14.3)d vs. (14.5±12.7)d],the incidence of FI[15.0%(3/20)vs.35.0%(7/20)]and the mortality [10.0%(2/20)vs. 25.0%(5/20)]were lower in prevention group,there were significant differences between the two groups(P<0.05).Conclusion Prophylactic antifungal treatment can shorten the hospital stay,delay the FI occurrence,reduce the incidence of FI and the mortality in patients with SAP.
