CAJ | 학술논문

目的观察二次聚焦超声辐射对小鼠腿部移植的宫颈癌U14肿瘤复发和转移的影响.方法将72只腿部移植成功的U14宫颈癌小鼠按随机数字表法随机分为一次辐射组、二次辐射组和手术切除组,每组小鼠24只.一次辐射组于移植肿瘤后第7天接受1次聚焦超声辐射治疗；二次辐射组于移植肿瘤后第7天接受1次聚焦超声辐射治疗,第8天接受第2次聚焦超声辐射治疗；手术切除组于移植肿瘤后第7天切除原发肿瘤.3组小鼠均于肿瘤移植后第23天检测其抑瘤率和抑制转移率.结果二次辐射组的抑瘤率和抑制转移率分别为61.70％和68.18％,显著高于一次辐射组的41.84％和31.82％,差异有统计学意义(P＜0.05).结论一次聚焦超声辐射和二次聚焦超声辐射对肿瘤的局部复发和转移均有明显的抑制作用,且二次聚焦超声辐射较一次聚焦超声辐射的治疗作用更强.
목적 관찰이차취초초성복사대소서퇴부이식적궁경암U14종류복발화전이적영향.방법 장72지퇴부이식성공적U14궁경암소서안수궤수자표법수궤분위일차복사조、이차복사조화수술절제조,매조소서24지.일차복사조우이식종류후제7천접수1차취초초성복사치료；이차복사조우이식종류후제7천접수1차취초초성복사치료,제8천접수제2차취초초성복사치료；수술절제조우이식종류후제7천절제원발종류.3조소서균우종류이식후제23천검측기억류솔화억제전이솔.결과 이차복사조적억류솔화억제전이솔분별위61.70％화68.18％,현저고우일차복사조적41.84％화31.82％,차이유통계학의의(P＜0.05).결론 일차취초초성복사화이차취초초성복사대종류적국부복발화전이균유명현적억제작용,차이차취초초성복사교일차취초초성복사적치료작용경강.
Objective To investigate the efficacy of twice irradiating with focused ultrasound on recurrent and metastasized U14 cervical cancer implanted in the legs of mice. Methods Seventy-two mice with U14 cervical cancer cells implanted in their legs were divided into three groups randomly,with 24 rats in each group.One group received a single dose of focused ultrasound,while mice in the second group were irradiated twice and surgery resection was administered to the third group 7 or 8 days after the tumor was implanted.After 23 days post implantation of the tumor,local tumor recurrence and metastasis to the lungs and lymph nodes were evaluated. Results The inhibition rate after double irradiation was 61.70％ for local recurrence and 68.18％ for metastasis,significantly higher than in the other two groups. Conclusions Both single and double irradiation with focused ultrasound are effective for inhibiting local recurrence and metastasis,but double irradiation is more effective.