国际呼吸杂志
國際呼吸雜誌
국제호흡잡지
INTERNATIONAL JOURNAL OF RESPIRATION
2008年
18期
1115-1118
,共4页
XRCC1%基因多态性%肺癌%化疗%放疗
XRCC1%基因多態性%肺癌%化療%放療
XRCC1%기인다태성%폐암%화료%방료
XRCC1%Genetic polymorphism%Lung cancer%Chemotherapy%Radiotherapy
X线修复交叉互补基因1(X-ray repair cross complementing 1,XRCC1)是一种重要的DNA修复基因,其编码的蛋白参与DNA单链断裂和碱基损伤修复,对维持细胞基因组的稳定性、预防肿瘤的发生有着重要的作用.本文对XRCC1基因的结构与功能以及基因多态性与肺癌易感性、肺癌放化疗疗效的关系的研究现状进行综述.
X線脩複交扠互補基因1(X-ray repair cross complementing 1,XRCC1)是一種重要的DNA脩複基因,其編碼的蛋白參與DNA單鏈斷裂和堿基損傷脩複,對維持細胞基因組的穩定性、預防腫瘤的髮生有著重要的作用.本文對XRCC1基因的結構與功能以及基因多態性與肺癌易感性、肺癌放化療療效的關繫的研究現狀進行綜述.
X선수복교차호보기인1(X-ray repair cross complementing 1,XRCC1)시일충중요적DNA수복기인,기편마적단백삼여DNA단련단렬화감기손상수복,대유지세포기인조적은정성、예방종류적발생유착중요적작용.본문대XRCC1기인적결구여공능이급기인다태성여폐암역감성、폐암방화료료효적관계적연구현상진행종술.
X-ray repair cross complementing I(XRCC1) plays a critical role in repair of single-strand breaks and base damage. So it is considered important in maintaining stability of genome and in the prevention of tumor occurrence. The article reviews the structure and function of XRCC1 gene, the relationship between genetic polymorphisms of XRCC1 and susceptibility to lung cancer, the association between genetic polymorphisms of XRCC1 and response to chemotherapy and radiotherapy,and prognosis in lung cancer. The studies of XRCC1 could offer theoretical reference in prevention and therapy of lung cancer.
