CAJ | 학술논문

纤溶系统失衡参与了缺血性卒中的病理生理学过程.大多数学者认为缺血性卒中患者的纤溶活性降低,而部分学者认为其纤溶活性增高.亚低温是一种具有巨大潜能并通过多种机制发挥神经保护效应的治疗手段.动物实验证实,亚低温治疗能提高血浆纤溶活性并减少缺血区局部纤溶酶原激活物表达,但相关临床研究较少,而且多局限于亚低温联合其他治疗方法的安全性和协同性的研究.
섬용계통실형삼여료결혈성졸중적병리생이학과정.대다수학자인위결혈성졸중환자적섬용활성강저,이부분학자인위기섬용활성증고.아저온시일충구유거대잠능병통과다충궤제발휘신경보호효응적치료수단.동물실험증실,아저온치료능제고혈장섬용활성병감소결혈구국부섬용매원격활물표체,단상관림상연구교소,이차다국한우아저온연합기타치료방법적안전성화협동성적연구.
The imbalance in the fibrinolytic system participates in the pathophysic-logical processes of ischemic stroke. Most researchers consider that the fibrinolytic activity decreases in patients with ischemic stroke, while others believe that it increases. Mild hypothermia is a therapeutic approach with great potential and plays the neuroprotective effect through a variety of mechanisms. Animal experiments have demonstrated that the treatment with mild hypothermia may increase the plasma fibrinolytic activity and decrease the expression of local plasminogen activator in ischemic area. Howere, the related clinical research studies are few, and most of them are limited in the safty and collaborative research of mild hypothermia combined with other treatment therapies.