CAJ | 학술논문

树突状细胞(DC)具有摄取、加工、处理和呈递抗原以及激活初始T淋巴细胞的功能,是体内功能最强的专职抗原递呈细胞,也是免疫应答的关键细胞.近年来研究发现,体外经肿瘤抗原刺激的DC回输到病人体内,能诱导机体产生细胞毒性T淋巴细胞,从而发挥特异性肿瘤杀伤作用.根据这一发现研制的DC疫苗目前在妇科肿瘤免疫治疗中已取得重要进展,因而受到日益广泛的关注.
수돌상세포(DC)구유섭취、가공、처리화정체항원이급격활초시T림파세포적공능,시체내공능최강적전직항원체정세포,야시면역응답적관건세포.근년래연구발현,체외경종류항원자격적DC회수도병인체내,능유도궤체산생세포독성T림파세포,종이발휘특이성종류살상작용.근거저일발현연제적DC역묘목전재부과종류면역치료중이취득중요진전,인이수도일익엄범적관주.
Dendritic cells are well known as the strongest antigen-presentation cells at present, which exert the effects of capturing, processing and presenting antigen, as well as sensitizing naive T cells. In vitro,cultureted dendritic cells stimulated by tumor antigen could induce the generation of cytotoxic T lymphocytes and lead to tumor-specific killing. Based on the finding, dendritic cells vaccine has been developed and some important application progress has been gained in immunotherapy for gynecological cancers at present. Therefore,more attention is focused on dendritic cells vaccine for gynecological cancers.