中华医学杂志
中華醫學雜誌
중화의학잡지
National Medical Journal of China
2010年
41期
2947-2948
,共2页
范荣%赫兢%张秀%姜天俊%谢杨新%周志平%闫慧颖%李文刚%涂波%赵敏
範榮%赫兢%張秀%薑天俊%謝楊新%週誌平%閆慧穎%李文剛%塗波%趙敏
범영%혁긍%장수%강천준%사양신%주지평%염혜영%리문강%도파%조민
流感%H1N1%淋巴细胞计数%C反应蛋白质%补体
流感%H1N1%淋巴細胞計數%C反應蛋白質%補體
류감%H1N1%림파세포계수%C반응단백질%보체
Influenza%H1N1%Lymphocyte count%C-reactive protein%Complement
目的 研究成人甲型H1N1流感患者血清免疫学和炎性指标在病程中的变化趋势及轻/重症患者的差异.方法 检测解放军第三○二医院2009年1～12月收治的148例轻症和18例重症患者急性期和恢复期的外周血白细胞、淋巴细胞、单核细胞计数和CD4+、CD8+T淋巴细胞绝对值,C反应蛋白、血清补体C3、C4和CH50,血清免疫球蛋白IgA、IgM和IgG,分析这些指标的变化.结果 两组患者急性期淋巴细胞数量下降和单核细胞数量上升,恢复期淋巴细胞数量回升和单核细胞数量回落.急性期重症组T淋巴细胞数量、CD4+和CD8+T细胞绝对值均明显低于轻症组.急性期两组CRP均上升,重症组较轻症组升高更明显;恢复期两组CRP较急性期均明显回落,但轻症组的回复快于重症组.急性期多数患者CH50有轻微上升,重症组CH50高于轻症组.结论 淋巴细胞计数、CD4+和CD8+T细胞绝对值及CRP、CH50等指标有助于监测病情轻重和判断预后.
目的 研究成人甲型H1N1流感患者血清免疫學和炎性指標在病程中的變化趨勢及輕/重癥患者的差異.方法 檢測解放軍第三○二醫院2009年1～12月收治的148例輕癥和18例重癥患者急性期和恢複期的外週血白細胞、淋巴細胞、單覈細胞計數和CD4+、CD8+T淋巴細胞絕對值,C反應蛋白、血清補體C3、C4和CH50,血清免疫毬蛋白IgA、IgM和IgG,分析這些指標的變化.結果 兩組患者急性期淋巴細胞數量下降和單覈細胞數量上升,恢複期淋巴細胞數量迴升和單覈細胞數量迴落.急性期重癥組T淋巴細胞數量、CD4+和CD8+T細胞絕對值均明顯低于輕癥組.急性期兩組CRP均上升,重癥組較輕癥組升高更明顯;恢複期兩組CRP較急性期均明顯迴落,但輕癥組的迴複快于重癥組.急性期多數患者CH50有輕微上升,重癥組CH50高于輕癥組.結論 淋巴細胞計數、CD4+和CD8+T細胞絕對值及CRP、CH50等指標有助于鑑測病情輕重和判斷預後.
목적 연구성인갑형H1N1류감환자혈청면역학화염성지표재병정중적변화추세급경/중증환자적차이.방법 검측해방군제삼○이의원2009년1～12월수치적148례경증화18례중증환자급성기화회복기적외주혈백세포、림파세포、단핵세포계수화CD4+、CD8+T림파세포절대치,C반응단백、혈청보체C3、C4화CH50,혈청면역구단백IgA、IgM화IgG,분석저사지표적변화.결과 량조환자급성기림파세포수량하강화단핵세포수량상승,회복기림파세포수량회승화단핵세포수량회락.급성기중증조T림파세포수량、CD4+화CD8+T세포절대치균명현저우경증조.급성기량조CRP균상승,중증조교경증조승고경명현;회복기량조CRP교급성기균명현회락,단경증조적회복쾌우중증조.급성기다수환자CH50유경미상승,중증조CH50고우경증조.결론 림파세포계수、CD4+화CD8+T세포절대치급CRP、CH50등지표유조우감측병정경중화판단예후.
Objective To study the difference of immunological and inflammatory indices between mild type and severe type of adult pandemic(H1N1)patients. Methods White blood cell, lymphocyte,monocyte, CD4+ and CD8 + T lymphocyte counts, level of C3 and C4, CH50, immunoglobulin A/G/M and CRP from 166 pandemic(H1N1)patients during acute and recovery phases were recorded and analyzed.Results A lowered lymphocyte count and an elevated monocyte count were observed in both groups during acute phase. And both were corrected during recovery phase. The absolute values of CD4 + and CD8 + T lymphocytes were much lower in severe group than those in mild group. During acute phase, the level of creactive protein(CRP)was elevated in both groups while it was higher in the severe group than that in the mild group. During recovery phase, the CRP level fell after a rise in both groups while it was quicker in the severe group than that in the mild group. During acute phase, the majority of CH50 became mildly elevated.And it was higher in severe patients than mild ones. Conclusion Lymphocyte count, CD4 + & CD8 + T lymphocyte counts and CRP & CH50 values provide useful information for the diagnosis of pandemic (H1N1)and the evaluation of its severity.
