CAJ | 학술논문

目的描述和探讨江苏省启东市50年肝癌死亡率的特征及其变化趋势.方法采用死亡回顾调查方法获得启东市1958-1971年肝癌死亡率资料,采用肿瘤登记方法获得启东市1972-2007年肝癌死亡率资料.分析肝癌的粗死亡率、中国人口标化率(中标率)和世界人口标化率(世标率)；用变化百分比(PC)和年度变化百分比(APC)来评价率的增长趋势,分析性别和年龄别死亡率、35～64岁截缩率、0～74岁累积死亡率、累积死亡风险和年龄-出生队列死亡率.结果 1958-2007年启东市人群自然死亡率经历了由8.62‰降至5.37‰再升至7.75‰的过程,恶性肿瘤死亡率由56.69/10万持续上升至234.97/10万,肝癌死亡率由20.45/10万上升至1972年的49.04/10万,再升至2007年的69.29/10万.根据肿瘤登记资料,1972-2007年期间启东市肝癌死亡占所有恶性肿瘤的34.88％,粗死亡率为58.86/10万,中标率为38.36/10万,世标率为49.37/10万.35～64岁的截缩率为117.08/10万,0～74岁的累积死亡率和累积死亡风险分别为5.15％和5.02％.启东男、女性肝癌粗死亡率分别为90.52/10万和27.93/10万,死亡率性别比为3.24:1.1972-2007年期间,粗死亡率的PC为49.71％,APC为1.41％,呈增长的趋势,但中标率和世标率的APC分别为- 1.11％和-0.84％,呈下降的趋势.各时期肝癌的年龄别死亡率显示,40～岁组及以下各年龄组死亡率呈明显的下降趋势.年龄-出生队列分析结果显示,35～岁组及以下各年龄组,即20世纪50年代以后出生的队列人群的肝癌死亡率均呈下降趋势.结论肝癌是江苏省启东市最主要的恶性肿瘤,肝癌粗死亡率持续保持在较高的水平,但标化率已呈现下降趋势；青年人群中的肝癌死亡率也出现了下降趋势.启东市的肝癌防控工作初见成效.
목적 묘술화탐토강소성계동시50년간암사망솔적특정급기변화추세.방법 채용사망회고조사방법획득계동시1958-1971년간암사망솔자료,채용종류등기방법획득계동시1972-2007년간암사망솔자료.분석간암적조사망솔、중국인구표화솔(중표솔)화세계인구표화솔(세표솔)；용변화백분비(PC)화년도변화백분비(APC)래평개솔적증장추세,분석성별화년령별사망솔、35～64세절축솔、0～74세루적사망솔、루적사망풍험화년령-출생대렬사망솔.결과 1958-2007년계동시인군자연사망솔경력료유8.62‰강지5.37‰재승지7.75‰적과정,악성종류사망솔유56.69/10만지속상승지234.97/10만,간암사망솔유20.45/10만상승지1972년적49.04/10만,재승지2007년적69.29/10만.근거종류등기자료,1972-2007년기간계동시간암사망점소유악성종류적34.88％,조사망솔위58.86/10만,중표솔위38.36/10만,세표솔위49.37/10만.35～64세적절축솔위117.08/10만,0～74세적루적사망솔화루적사망풍험분별위5.15％화5.02％.계동남、녀성간암조사망솔분별위90.52/10만화27.93/10만,사망솔성별비위3.24:1.1972-2007년기간,조사망솔적PC위49.71％,APC위1.41％,정증장적추세,단중표솔화세표솔적APC분별위- 1.11％화-0.84％,정하강적추세.각시기간암적년령별사망솔현시,40～세조급이하각년령조사망솔정명현적하강추세.년령-출생대렬분석결과현시,35～세조급이하각년령조,즉20세기50년대이후출생적대렬인군적간암사망솔균정하강추세.결론 간암시강소성계동시최주요적악성종류,간암조사망솔지속보지재교고적수평,단표화솔이정현하강추세；청년인군중적간암사망솔야출현료하강추세.계동시적간암방공공작초견성효.
Objective To describe and analyze the charecteristics and trends of liver cancer mortality during the past fifty years in Qidong,China.Methods Retrospective mortality survey was conducted to get the data on liver cancer death in the period of 1958-1971,and the data from 1972 to 2007 were obtained from the records of cancer registration in Qidong.The crude mortality rate ( CR ) of liver cancer,and age-standardized rate by Chinese population (CASR) and by world population (WASR) were calculated and analyzed.The total percent changes (PC) and annual percent changes (APC) were used for evaluating the increasing trends of the mortality.The sex-specific rate,age-specific rate,truncated rate of the age group 35-64,cumulative rate of the age group 0-74,cumulative risk,period-rate,and the rate for age-birth cohort were compared.Results The natural death rate in Qidong residents for the past five-decade period experienced a wave interval of 8.62‰ in 1958 down to 5.37‰ in 1979,and up to 7.75‰ in 2007.The mortality rate for all-site cancers was increased from 56.69 per 100,000 to 234.97 per 100,000.The mortality rate of liver cancer,being 20.45 per 100,100 in 1958 was increased to 49.04 per 100,000 in 1972,and up to 69.29 per 100,000 in 2007.According to the registration data of 1972-2007,the death from liver cancer was accounted for 34.88％ of all deaths due to cancers,with a CR of 58.86 per 100,000,CASR of 38.36 per 100,000,and WASR,49.37 Per 100,000 in Qidong.The truncated rate for the age group 35-64 was 117.08 per 100,000,and the cumulative rate for the age group 0-74 and the cumulative risk were 5.15％ and 5.02％,respectively.The CRs for males was 90.52 per 100,000 and for females was 27.93 per 100,000,with a sex ratio of 3.24∶1.For the period of 1972-2007,the PC for CR was 49.71％,and APC was + 1.41％,showing an increasing variation tendency.The APCs for CASR and WASR,however,were decreasing,with a percentage of - 1.11％,and -0.84％,respectively.The age-specific mortality rates by period showed a decreasing trend for those under age of 44.Moreover,age-birth cohort analysis showed a more rapid lowering mortality in the age groups 35-,30-,25-,and 15-,that is,those born after 1950's.Conclusions Liver cancer remains the leading death cause due to cancers in Qidong,with a continuing higher crude mortality rate.Yet the age-standardized mortality rate has presented a declining posture.The liver cancer mortality in young people in Qidong demonstrates a continuously falling trend.The campaign for the control of liver cancer in Qidong has achieved initial success.