中华妇产科杂志
中華婦產科雜誌
중화부산과잡지
CHINESE JOUNAL OF OBSTETRICS AND GYNECOLOGY
2012年
9期
672-675
,共4页
付景冉%卢丽娜%余莉萍%王冬昱%丁堪铄
付景冉%盧麗娜%餘莉萍%王鼕昱%丁堪鑠
부경염%로려나%여리평%왕동욱%정감삭
子宫内膜肿瘤%脂联素%胰岛素抗药性
子宮內膜腫瘤%脂聯素%胰島素抗藥性
자궁내막종류%지련소%이도소항약성
Endometrial neoplasms%Adiponectin%Insulin resistance
目的 检测子宫内膜癌患者血清脂联素水平及胰岛素抵抗指数,探讨其临床意义及相关性.方法 检测2009年9月至201 1年7月在广州市第一人民医院治疗的35例子宫内膜癌患者(分为A1组:初诊子宫内膜癌未绝经组20例,A2组:初诊子宫内膜癌绝经组15例)和同期门诊体检妇女30例(对照组)的血清脂联素、空腹胰岛素和空腹血糖水平,以稳态模型评估法计算胰岛素抵抗指数(HOMA-4R).结果 A1组患者血清脂联素水平下降、HOMA-IR升高,分别为(6.7±1.1)ng/L、3.5±1.8,分别与A2组[分别为(9.2±1.0)ng/L、2.9±1.0]、对照组[分别为(10.0±1.4) ng/L、1.1±0.7]比较,差异均有统计学意义(P＜0.05);A2组与对照组比较,差异无统计学意义(P＞0.05)；且脂联素水平越低,HOMA-IR越高,两者呈明显负相关(r=-0.389,P＜0.05).结论 子宫内膜癌未绝经患者脂联素水平降低且胰岛素抵抗,促进了子宫内膜癌发病,是其发病的危险冈素.
目的 檢測子宮內膜癌患者血清脂聯素水平及胰島素牴抗指數,探討其臨床意義及相關性.方法 檢測2009年9月至201 1年7月在廣州市第一人民醫院治療的35例子宮內膜癌患者(分為A1組:初診子宮內膜癌未絕經組20例,A2組:初診子宮內膜癌絕經組15例)和同期門診體檢婦女30例(對照組)的血清脂聯素、空腹胰島素和空腹血糖水平,以穩態模型評估法計算胰島素牴抗指數(HOMA-4R).結果 A1組患者血清脂聯素水平下降、HOMA-IR升高,分彆為(6.7±1.1)ng/L、3.5±1.8,分彆與A2組[分彆為(9.2±1.0)ng/L、2.9±1.0]、對照組[分彆為(10.0±1.4) ng/L、1.1±0.7]比較,差異均有統計學意義(P＜0.05);A2組與對照組比較,差異無統計學意義(P＞0.05)；且脂聯素水平越低,HOMA-IR越高,兩者呈明顯負相關(r=-0.389,P＜0.05).結論 子宮內膜癌未絕經患者脂聯素水平降低且胰島素牴抗,促進瞭子宮內膜癌髮病,是其髮病的危險岡素.
목적 검측자궁내막암환자혈청지련소수평급이도소저항지수,탐토기림상의의급상관성.방법 검측2009년9월지201 1년7월재엄주시제일인민의원치료적35례자궁내막암환자(분위A1조:초진자궁내막암미절경조20례,A2조:초진자궁내막암절경조15례)화동기문진체검부녀30례(대조조)적혈청지련소、공복이도소화공복혈당수평,이은태모형평고법계산이도소저항지수(HOMA-4R).결과 A1조환자혈청지련소수평하강、HOMA-IR승고,분별위(6.7±1.1)ng/L、3.5±1.8,분별여A2조[분별위(9.2±1.0)ng/L、2.9±1.0]、대조조[분별위(10.0±1.4) ng/L、1.1±0.7]비교,차이균유통계학의의(P＜0.05);A2조여대조조비교,차이무통계학의의(P＞0.05)；차지련소수평월저,HOMA-IR월고,량자정명현부상관(r=-0.389,P＜0.05).결론 자궁내막암미절경환자지련소수평강저차이도소저항,촉진료자궁내막암발병,시기발병적위험강소.
Objective To explore changes of serum adiponectin and insulin resistance in patients with endometrial cancer and to evaluate the clinical significance and correlation.Methods The serum levels of adiponectin and fasting insulin were determined by ELISA, electro-chemilluminometry and radioimmunoassay in 35 patients with endometrial cancer [ all patients divided into two groups,A1 group belonged to without postmenopausal when first visiting (n =20),A2 group belonged to postmenopausal when first visiting (n ＝ 15 ) ] and 30 cases of health control.The result of homeostasis nodel assessment-insulin resistance (HOMA-IR) index was calculated.Results The levels of adiponectin in A1 group was lower than that ofhealth control group [(6.7±1.1) versus (10.0 ±1.4) ng/L,P＜0.05],and HOMA-IR was higher than that of health control group ( 3.5 ± 1.8 versus 1.1 ± 0.7,P ＜ 0.05 ).While there were not significant difference between A2 group and health control group (P ＞ 0.05 ).Adiponectin and insulin resistance was negatively correlated ( r =- 0.389,P ＜ 0.05 ).Conclusion Adiponectin reducing and insulin resistance in reproductive age patients may be the independent factors to promote endometrial cancers.
