CAJ | 학술논문

ras 是一类与恶性肿瘤密切相关的蛋白,其持续活化可促进肿瘤的发生发展.RASAL1蛋白是一种钙离子介导的 ras GTP 酶活化蛋白,其表达下降或缺失,可使 ras 活化,从而导致肿瘤的发生发展.本文综述 ras 活性调节机制、RASAL1 与恶性肿瘤的关系以及RASAL1的表达下调的相关机制.
ras 시일류여악성종류밀절상관적단백,기지속활화가촉진종류적발생발전.RASAL1단백시일충개리자개도적 ras GTP 매활화단백,기표체하강혹결실,가사 ras 활화,종이도치종류적발생발전.본문종술 ras 활성조절궤제、RASAL1 여악성종류적관계이급RASAL1적표체하조적상관궤제.
Ras is a kind of protein closely related to neoplasms,the persistent activation of which would induce tumorigenesis and progression.RASAL1 is a Ca~(2+) regulated ras GTPase-activating-like protein, the loss or decreased expression of RASAL1 induces ras activation, then results in tumongenesis and progression.In this review we sum up the mechanism of ras activation, the relationship between neoplasms and RASAL1 and the mechanism of RASAL1 expression decreasing.