CAJ | 학술논문

研究高游离脂肪酸(FFA)血症所致大鼠机体氧化应激及胰岛素抵抗之间的相互关系,以及其对机体抗氧化能力的影响,探讨胰岛素抵抗的病理生理机制.经研究证实大鼠高FFA血症不仅使组织活性氧簇生成增加[(886±105 vs 427±42)mmol/L,P<0.05],同时损伤机体抗氧化能力,细胞内还原捌谷胱甘肽生成减少[(272±47 vs 561±36)μmol/L,P<0.05],导致氧化应激,从而促进胰岛素抵抗的形成.
연구고유리지방산(FFA)혈증소치대서궤체양화응격급이도소저항지간적상호관계,이급기대궤체항양화능력적영향,탐토이도소저항적병리생리궤제.경연구증실대서고FFA혈증불부사조직활성양족생성증가[(886±105 vs 427±42)mmol/L,P<0.05],동시손상궤체항양화능력,세포내환원팔곡광감태생성감소[(272±47 vs 561±36)μmol/L,P<0.05],도치양화응격,종이촉진이도소저항적형성.
The relationship between elevated concentration of circulating free fatty acids (FFA) and insulin resistance wag studied,and the pathophysiological mechanism of insulin resistance,especially focused on oxidative stress,was explored.It was found that the elevated circulating FFA level led to insulin resistance in rats, which was partly caused by oxidative stress,and that antioxidative treatment was able to reverse the pathologic change.As a result of enhancing reactive oxygen species production[(886±105 vs 427±42)mmol/L,P<0.05] and disrupting antioxidant[(272±47 vs 561±36)μmol/L,P<0.05],elevated concentration of FFA may induce oxidative stress.