中华糖尿病杂志
中華糖尿病雜誌
중화당뇨병잡지
CHINES JOURNAL OF DLABETES MELLITUS
2012年
4期
234-237
,共4页
南金延%管玥琰%邢春燕%谭晓俊%刘煜
南金延%管玥琰%邢春燕%譚曉俊%劉煜
남금연%관모염%형춘연%담효준%류욱
甲状腺肿%受体,甲状腺激素%谷氨酸脱羧酶%锌转运体8
甲狀腺腫%受體,甲狀腺激素%穀氨痠脫羧酶%鋅轉運體8
갑상선종%수체,갑상선격소%곡안산탈최매%자전운체8
Goiter%Receptors,thyroid hormone%Glutamate decarboxylase%Zinc transporter 8
目的 探讨Graves病患者促甲状腺激素受体抗体、锌转运体8抗体、谷氨酸脱羧酶抗体水平及其相关性.方法 招募2009年11月至2011年3月吉林大学白求恩第二医院内分泌科门诊和病房收治的51例Graves病患者(Graves病组；男9例,女42例)及72例1型糖尿病患者(1型糖尿病组；男30例,女42例),另以70名志愿者为健康对照组.利用放射免疫分析法检测各组血清促甲状腺激素受体抗体水平,采用放射免疫沉淀法检测锌转运体8抗体及谷氨酸脱羧酶抗体水平.Pearson相关分析进行组间相关性分析.结果 Graves病组促甲状腺激素受体抗体、锌转运体8抗体、谷氨酸脱羧酶抗体的阳性率分别为90.2％(46/51)、15.7％(8/51)和5.9％(3/51),1型糖尿病组上述3种抗体的阳性率依次为4.2％( 3/72)、45.8％ (33/72)和41.7％(30/72),健康对照组上述3种抗体的阳性率依次为0、1.4％(1/70)和1.4％ (1/70).Graves病组促甲状腺激素受体抗体与锌转运体8抗体呈正线性相关(r =0.278,P＜0.05)；促甲状腺激素受体抗体阳性的Graves病患者促甲状腺激素受体抗体与锌转运体8抗体呈正线性相关(r =0.537,P＜0.01).1型糖尿病组锌转运体8抗体与谷氨酸脱羧酶抗体呈明显正线性相关(r =0.892,P＜0.01).结论 自身免疫性甲状腺病与自身免疫性糖尿病可能存在一定关联.1型糖尿病患者锌转运体8抗体水平与谷氨酸脱羧酶抗体水平高度相关.
目的 探討Graves病患者促甲狀腺激素受體抗體、鋅轉運體8抗體、穀氨痠脫羧酶抗體水平及其相關性.方法 招募2009年11月至2011年3月吉林大學白求恩第二醫院內分泌科門診和病房收治的51例Graves病患者(Graves病組；男9例,女42例)及72例1型糖尿病患者(1型糖尿病組；男30例,女42例),另以70名誌願者為健康對照組.利用放射免疫分析法檢測各組血清促甲狀腺激素受體抗體水平,採用放射免疫沉澱法檢測鋅轉運體8抗體及穀氨痠脫羧酶抗體水平.Pearson相關分析進行組間相關性分析.結果 Graves病組促甲狀腺激素受體抗體、鋅轉運體8抗體、穀氨痠脫羧酶抗體的暘性率分彆為90.2％(46/51)、15.7％(8/51)和5.9％(3/51),1型糖尿病組上述3種抗體的暘性率依次為4.2％( 3/72)、45.8％ (33/72)和41.7％(30/72),健康對照組上述3種抗體的暘性率依次為0、1.4％(1/70)和1.4％ (1/70).Graves病組促甲狀腺激素受體抗體與鋅轉運體8抗體呈正線性相關(r =0.278,P＜0.05)；促甲狀腺激素受體抗體暘性的Graves病患者促甲狀腺激素受體抗體與鋅轉運體8抗體呈正線性相關(r =0.537,P＜0.01).1型糖尿病組鋅轉運體8抗體與穀氨痠脫羧酶抗體呈明顯正線性相關(r =0.892,P＜0.01).結論 自身免疫性甲狀腺病與自身免疫性糖尿病可能存在一定關聯.1型糖尿病患者鋅轉運體8抗體水平與穀氨痠脫羧酶抗體水平高度相關.
목적 탐토Graves병환자촉갑상선격소수체항체、자전운체8항체、곡안산탈최매항체수평급기상관성.방법 초모2009년11월지2011년3월길림대학백구은제이의원내분비과문진화병방수치적51례Graves병환자(Graves병조；남9례,녀42례)급72례1형당뇨병환자(1형당뇨병조；남30례,녀42례),령이70명지원자위건강대조조.이용방사면역분석법검측각조혈청촉갑상선격소수체항체수평,채용방사면역침정법검측자전운체8항체급곡안산탈최매항체수평.Pearson상관분석진행조간상관성분석.결과 Graves병조촉갑상선격소수체항체、자전운체8항체、곡안산탈최매항체적양성솔분별위90.2％(46/51)、15.7％(8/51)화5.9％(3/51),1형당뇨병조상술3충항체적양성솔의차위4.2％( 3/72)、45.8％ (33/72)화41.7％(30/72),건강대조조상술3충항체적양성솔의차위0、1.4％(1/70)화1.4％ (1/70).Graves병조촉갑상선격소수체항체여자전운체8항체정정선성상관(r =0.278,P＜0.05)；촉갑상선격소수체항체양성적Graves병환자촉갑상선격소수체항체여자전운체8항체정정선성상관(r =0.537,P＜0.01).1형당뇨병조자전운체8항체여곡안산탈최매항체정명현정선성상관(r =0.892,P＜0.01).결론 자신면역성갑상선병여자신면역성당뇨병가능존재일정관련.1형당뇨병환자자전운체8항체수평여곡안산탈최매항체수평고도상관.
Objective To investigate the relationship between thyroid-stimulating hormone receptor antibody (TRAb),zinc transporter 8 antibody (ZnT8A) and glutamic acid decarboxylase antibody (GADA) in patients with Graves' disease (GD).Methods A total of 51 GD patients (9 male,42 female) and 72type 1 diabetes mellitus(T1DM) patients (30 male,42 female) were collected from outpatient and inpatient department of our hospital from November 2009 to March 2011,and 70 healthy volunteers (29 male,41female)were recruited as control group.The serum levels of TRAb,ZnT8A and GADA were detected by radioimmunoprecipitation and radioimmunoassay methods,respectively.Pearson' s correlation coefficient was used to evaluate the correlation between the autoantibodies. Results The positive rate of TRAb,ZnT8A and GADA in the GD group was 90.2％ (46/51),15.7％ (8/51) and 5.9％ (3/51),respectively.The positive rate of TRAb,ZnT8A and GADA in the T1DM group was 4.2％ (3/72),45.8％ (33/72) and 41.7％ (30/72),respectively.The positive rate of TRAb,ZnT8A and GADA in the health control group was 0,1.4％ (1/70) and 1.4％ (1/70),respectively.There was a positive correlation between TRAb and ZnT8A in GD patients,and the correlation was even stronger in TRAb positive GD patients ( r =0.537,P ＜0.01).There also showed a strong positive linear correlation between GADA and ZnT8A in T1DM patients ( r =0.892,P ＜ 0.01 ).Conclusion TRAb may be related with ZnT8A level in GD patients.ZnT8 and TRAb testing may help to diagnose and predict prognosis of GD.
