CAJ | 학술논문

目的建立猪急性心力衰竭的外科实验模型,采用连续心指数(CCI)监测评价心功能状态.方法采用冠状动脉结扎法尝试建立猪(n=6)急性心力衰竭模型.使用Swan-Ganz导管及Vigilance监护仪获取CCI,结合血流动力学、生化及心脏超声等指标评价心功能.结果 5只动物成功建模.与基础状态比较,急性心力衰竭状态下动物的平均动脉压(MAP)、肺动脉收缩压(PASP)、混合静脉氧饱和度(SVO_2)等血流动力学指标和CCI均发生具有统计学意义的变化(P<0.05);血生化指标未见明显改变;左心室射血分数(LVEF)明显下降(P<0.05).结论运用CCI监测和评价动物模型的心功能状态是可行的.以冠状动脉结扎法制备的猪急性心力衰竭模型,基本可满足外科实验研究的需要.
목적 건립저급성심력쇠갈적외과실험모형,채용련속심지수(CCI)감측평개심공능상태.방법 채용관상동맥결찰법상시건립저(n=6)급성심력쇠갈모형.사용Swan-Ganz도관급Vigilance감호의획취CCI,결합혈류동역학、생화급심장초성등지표평개심공능.결과 5지동물성공건모.여기출상태비교,급성심력쇠갈상태하동물적평균동맥압(MAP)、폐동맥수축압(PASP)、혼합정맥양포화도(SVO_2)등혈류동역학지표화CCI균발생구유통계학의의적변화(P<0.05);혈생화지표미견명현개변;좌심실사혈분수(LVEF)명현하강(P<0.05).결론 운용CCI감측화평개동물모형적심공능상태시가행적.이관상동맥결찰법제비적저급성심력쇠갈모형,기본가만족외과실험연구적수요.
Objective To establish the swine acute heart failure model for surgical experiment, and evaluate the heart function by continuous cardiac index (CCI). Methods Swine heart failure model was attempted to establish by coronary ligation in six swines. CCI was obtained by Swan-Canz catheters and Vigilance monitor, and hemodynamic, biochemical and ultrasonocardiographic results were utilized to evaluate the changes of heart function. Results Five swines accomplished the experiment. Compared with basic status, there were significant differences in mean arterial pressure (MAP) , pulmonary artery systolic pressure (PASP), mixed venous oxygen saturation ( SVO_2) and CCI for swines with heart failure ( P < 0.05) , there was no significant change in biochemical parameters, while left ventricle ejection fraction ( LVEF) significantly decreased (P<0.05). Conclusion CCI is feasible in monitoring and evaluating heart function of animal model. The swine acute heart failure model established by coronary ligations can meet the needs of surgical experiment in principle.