CAJ | 학술논문

为了寻找新的高效、低毒灭螺药,以取代苯乙腈为原料,经成肟、磷酰化等反应,制得9个新的二异丙基磷酸酯类化合物(3a ～3i),其结构经元素分析、IR、~1H NMR和MS确证.初步杀螺活性筛选结果表明,化合物3b和3h具有显著的杀螺活性,其半致死浓度LC_(50)值分别为 0.50 mg/L 和0.35 mg/L.
위료심조신적고효、저독멸라약,이취대분을정위원료,경성우、린선화등반응,제득9개신적이이병기린산지류화합물(3a ～3i),기결구경원소분석、IR、~1H NMR화MS학증.초보살라활성사선결과표명,화합물3b화3h구유현저적살라활성,기반치사농도LC_(50)치분별위 0.50 mg/L 화0.35 mg/L.
In order to search for novel more effective and less toxic molluscicides,nine new diisopropyl phosphates (3a-3i) were synthesized from substituted phenylacetonitriles by oximation and phosphorylation.The new compounds were confirmed by elemental analyses,IR,~1H NMR and MS.Preliminary biological screening showed that compounds 3b and 3h appeared to have significant molluscicidal activity against Oncomelanis hwpensis snails.The LC_(50) value of the compounds 3b and 3h against snails were 0.50 mg/L and 0.35 mg/L,respectively.