中华普通外科杂志
中華普通外科雜誌
중화보통외과잡지
CHINESE JOURNAL OF GENERAL SURGERY
2009年
5期
413-415
,共3页
赵敬敬%孟凡坤%李娟%何玉兰%侯维%卢实春%于红卫%赵娟%刘钊%李宁%孟庆华
趙敬敬%孟凡坤%李娟%何玉蘭%侯維%盧實春%于紅衛%趙娟%劉釗%李寧%孟慶華
조경경%맹범곤%리연%하옥란%후유%로실춘%우홍위%조연%류쇠%리저%맹경화
肝功能试验%肝肿瘤%肝硬化%吲哚氰绿
肝功能試驗%肝腫瘤%肝硬化%吲哚氰綠
간공능시험%간종류%간경화%신타청록
Liver function test%Liver neoplasms%Liver cirrhosis%Indocyanine green
目的 探讨脉动色素浓度测定(PDD)吲哚氰绿(ICG)潴留试验对于评价肝硬化与肝癌肝储备功能的临床价值.方法 选取89例肝炎肝硬化患者和40例原发性肝癌患者,以PDD法测定ICG 15 win潴留率(ICGR15)及常规临床指标CHE、PAB、ALB、PTA、TBA;比较ICGRl5与以上临床指标对肝功能评价的意义,并各指标进行相关性分析.结果 (1)ICGR15、CHE、TBA、ALB、PTA在Child-Pugh A、B、C级3组比较,差异均有统计学意义(F=40.975,13.397,27.448,9.544,20.421,P<0.05),PAB在B级与A级、C级与A级之间差异有统计学意义(F=16.627,P<0.05).(2)肝炎肝硬化患者ICGRl5和TBA随Child-Push分值(C-P值)增加而递增,PTA则递减;ICGR15分别在C-P值5分与7分,9分与10分比较,差异有统计学意义(F=12.635,P<0.05).(3)ICGR15值与常用临床指标作相关性分析得出,与ICGR15值相关性最好的为TBA(r=0.605),其次为PTA、CHE、PAB、ALB(r=-0.598,-0.565,-0.537,-0.424).结论 PDD法ICGRl5与常规临床指标存在良好相关性,且明显优于常规肝功能指标,CHE、TBA也能够客观地评价肝储备状况.
目的 探討脈動色素濃度測定(PDD)吲哚氰綠(ICG)潴留試驗對于評價肝硬化與肝癌肝儲備功能的臨床價值.方法 選取89例肝炎肝硬化患者和40例原髮性肝癌患者,以PDD法測定ICG 15 win潴留率(ICGR15)及常規臨床指標CHE、PAB、ALB、PTA、TBA;比較ICGRl5與以上臨床指標對肝功能評價的意義,併各指標進行相關性分析.結果 (1)ICGR15、CHE、TBA、ALB、PTA在Child-Pugh A、B、C級3組比較,差異均有統計學意義(F=40.975,13.397,27.448,9.544,20.421,P<0.05),PAB在B級與A級、C級與A級之間差異有統計學意義(F=16.627,P<0.05).(2)肝炎肝硬化患者ICGRl5和TBA隨Child-Push分值(C-P值)增加而遞增,PTA則遞減;ICGR15分彆在C-P值5分與7分,9分與10分比較,差異有統計學意義(F=12.635,P<0.05).(3)ICGR15值與常用臨床指標作相關性分析得齣,與ICGR15值相關性最好的為TBA(r=0.605),其次為PTA、CHE、PAB、ALB(r=-0.598,-0.565,-0.537,-0.424).結論 PDD法ICGRl5與常規臨床指標存在良好相關性,且明顯優于常規肝功能指標,CHE、TBA也能夠客觀地評價肝儲備狀況.
목적 탐토맥동색소농도측정(PDD)신타청록(ICG)저류시험대우평개간경화여간암간저비공능적림상개치.방법 선취89례간염간경화환자화40례원발성간암환자,이PDD법측정ICG 15 win저류솔(ICGR15)급상규림상지표CHE、PAB、ALB、PTA、TBA;비교ICGRl5여이상림상지표대간공능평개적의의,병각지표진행상관성분석.결과 (1)ICGR15、CHE、TBA、ALB、PTA재Child-Pugh A、B、C급3조비교,차이균유통계학의의(F=40.975,13.397,27.448,9.544,20.421,P<0.05),PAB재B급여A급、C급여A급지간차이유통계학의의(F=16.627,P<0.05).(2)간염간경화환자ICGRl5화TBA수Child-Push분치(C-P치)증가이체증,PTA칙체감;ICGR15분별재C-P치5분여7분,9분여10분비교,차이유통계학의의(F=12.635,P<0.05).(3)ICGR15치여상용림상지표작상관성분석득출,여ICGR15치상관성최호적위TBA(r=0.605),기차위PTA、CHE、PAB、ALB(r=-0.598,-0.565,-0.537,-0.424).결론 PDD법ICGRl5여상규림상지표존재량호상관성,차명현우우상규간공능지표,CHE、TBA야능구객관지평개간저비상황.
Objective To investigate the efficacy of ICG clearance test for hepatic reserve function in patients with hepatic cirrhosis and primary liver carcinoma by pulse dye deusitometry (PDD). Methods Eighty-nine patients with hepatic cirrhosis and forty patients with primary hver carcinoma were enrolled in this study. All patients were classified by Child-Pugh grade. The value of indocyanin green retention at 15 min (ICGRI5) was measured by PDD. Biochemical parameters including CHE, PAB, ALB, PTA and TBA were also examined. Correlation analysis between ICGR15 and those indexes were conducted. Results (1) ICGR15, CHE, TBA, ALB, PTA among Child-Pugh A, B, C in all patients were significantly different (P < 0.05). PAB between Child-Pugh B and A group, C and B group was significantly different (P < 0.05). (2)Increased level of ICGR15 and TBA positively correlated with Child-Pugh scores, while negatively correlated with the level of PTA. The difference of ICGRI5 between Child-Pugh score 5 and score 7, score 9 and score 10 were all significant (P <0.05). (3) The correlation between ICGR15 and other clinical markers is significant. The clinical marker with the best correlation was TBA (r=0.605), was the parameter in most significantly correlated with ICGR15 followed by PTA, CHE, PAB, and ALB (r= -0.598, -0.565, -0.537, -0.424). Conclusion There was good correlation between the clinical markers and the value of ICGR15 which demonstrate superiority to the other indexes. The data also suggested that CHE, TBA, could be used in evaluating liver reserve function.
