国际遗传学杂志
國際遺傳學雜誌
국제유전학잡지
INTERNATIONAL JOURNAL OF GENETICS
2009年
1期
57-61
,共5页
RASSF1A%抑癌基因%甲基化%肺癌
RASSF1A%抑癌基因%甲基化%肺癌
RASSF1A%억암기인%갑기화%폐암
RASSF1A%Tumor suppressor gene%Methylation%Lung cancer
新近在肺癌和乳腺癌的研究中发现的Ras相关区域家族1A(Ras-association domain family 1A,RASSF1A)基因位于染色体3p21.3,是一种新型的肿瘤抑制基因(tumor suppressor gene,TSG).研究表明,RASSF1A主要通过介导细胞凋亡、阻断细胞周期进展等机制发挥抑癌作用,而该基因的表遗传失活与肺癌等多种恶性肿瘤的发生、发展和预后密切相关.同时其高甲基化的启动子可能是一种新的肿瘤标记物,可应用于肿瘤的诊断、治疗及其他众多领域,有着广阔的临床应用前景.
新近在肺癌和乳腺癌的研究中髮現的Ras相關區域傢族1A(Ras-association domain family 1A,RASSF1A)基因位于染色體3p21.3,是一種新型的腫瘤抑製基因(tumor suppressor gene,TSG).研究錶明,RASSF1A主要通過介導細胞凋亡、阻斷細胞週期進展等機製髮揮抑癌作用,而該基因的錶遺傳失活與肺癌等多種噁性腫瘤的髮生、髮展和預後密切相關.同時其高甲基化的啟動子可能是一種新的腫瘤標記物,可應用于腫瘤的診斷、治療及其他衆多領域,有著廣闊的臨床應用前景.
신근재폐암화유선암적연구중발현적Ras상관구역가족1A(Ras-association domain family 1A,RASSF1A)기인위우염색체3p21.3,시일충신형적종류억제기인(tumor suppressor gene,TSG).연구표명,RASSF1A주요통과개도세포조망、조단세포주기진전등궤제발휘억암작용,이해기인적표유전실활여폐암등다충악성종류적발생、발전화예후밀절상관.동시기고갑기화적계동자가능시일충신적종류표기물,가응용우종류적진단、치료급기타음다영역,유착엄활적림상응용전경.
RASSF1A is one of the most important transcripts of Ras-association Domain Family 1 (RASSF1)Gene,which is localized at chromosome 3p21.3.RASSFlA has been identified as a new tumor suppressor gene(TSG)due to its carcinoma preventive effect found in the recent studies of lung and breast cancers.It indicates that the loss of RASSFlA mRNA expression correlates well with the occurrence and development of lung cancer and several other human tumors.As the methylation of RASSF1A promoter region CpG island is an important event in the epigenetic inactivation of the gene,which can be detected in body fluids of patients.Hypermethylation of RASSFlA promoter can possibly be used as a new tumor marker,applying to the early cancer diagnosis,treatment,prognosis and many other fields,so RASSF1A gene will have a broad clinical application prospect.
