中华放射肿瘤学杂志
中華放射腫瘤學雜誌
중화방사종류학잡지
CHINESE JOURNAL OF RADIATION ONCOLOGY
2009年
1期
33-36
,共4页
严珊珊%刘志刚%刘莉%宋立兵%曾木圣%夏云飞
嚴珊珊%劉誌剛%劉莉%宋立兵%曾木聖%夏雲飛
엄산산%류지강%류리%송립병%증목골%하운비
鼻咽肿瘤%Ku70%DNA双链断裂%免疫组织化学
鼻嚥腫瘤%Ku70%DNA雙鏈斷裂%免疫組織化學
비인종류%Ku70%DNA쌍련단렬%면역조직화학
Nasopharyngeal carcinoma%KuT0%DNA double-strand break%Immunohisto chemistry
目的 探讨Ku70在鼻咽癌中的表达及其临床意义.方法 采用免疫组化SP法检测223例鼻咽癌石蜡标本中Ku70的表达情况,根据免疫反应强弱将其分为高表达和低表达两组(阴性表达归入低表达组),并结合临床资料分析Ku70表达高低与患者的临床病理特征及预后的关系.结果 Ku70在鼻咽癌组织中的高表达率为63.7%.单因素生存分析显示Ku70高表达组总生存率低于低表达组(x2=7.88,P=0.005),多因素分析显示性别、年龄、病理分型不是预后独立影响因素(x2=0.08、1.04、2.34,P=0.780、0.308、0.126),T、N、M分期是预后独立影响因素(x2=8.02、7.22、36.86,P=0.005、0.007、0.000),Ku70对鼻咽癌预后的独立影响接近临界值(x2=2.94,P=0.085).结论 初步研究发现Ku70对评价鼻咽痛的预后有参考价值,对患者预后的判断有一定的指导意义.
目的 探討Ku70在鼻嚥癌中的錶達及其臨床意義.方法 採用免疫組化SP法檢測223例鼻嚥癌石蠟標本中Ku70的錶達情況,根據免疫反應彊弱將其分為高錶達和低錶達兩組(陰性錶達歸入低錶達組),併結閤臨床資料分析Ku70錶達高低與患者的臨床病理特徵及預後的關繫.結果 Ku70在鼻嚥癌組織中的高錶達率為63.7%.單因素生存分析顯示Ku70高錶達組總生存率低于低錶達組(x2=7.88,P=0.005),多因素分析顯示性彆、年齡、病理分型不是預後獨立影響因素(x2=0.08、1.04、2.34,P=0.780、0.308、0.126),T、N、M分期是預後獨立影響因素(x2=8.02、7.22、36.86,P=0.005、0.007、0.000),Ku70對鼻嚥癌預後的獨立影響接近臨界值(x2=2.94,P=0.085).結論 初步研究髮現Ku70對評價鼻嚥痛的預後有參攷價值,對患者預後的判斷有一定的指導意義.
목적 탐토Ku70재비인암중적표체급기림상의의.방법 채용면역조화SP법검측223례비인암석사표본중Ku70적표체정황,근거면역반응강약장기분위고표체화저표체량조(음성표체귀입저표체조),병결합림상자료분석Ku70표체고저여환자적림상병리특정급예후적관계.결과 Ku70재비인암조직중적고표체솔위63.7%.단인소생존분석현시Ku70고표체조총생존솔저우저표체조(x2=7.88,P=0.005),다인소분석현시성별、년령、병리분형불시예후독립영향인소(x2=0.08、1.04、2.34,P=0.780、0.308、0.126),T、N、M분기시예후독립영향인소(x2=8.02、7.22、36.86,P=0.005、0.007、0.000),Ku70대비인암예후적독립영향접근림계치(x2=2.94,P=0.085).결론 초보연구발현Ku70대평개비인통적예후유삼고개치,대환자예후적판단유일정적지도의의.
Objective To investigate the expression and clinical significance of Ku70 in nasopha ryngeal oarcinoma(NPC).Methods The expression of Ku70 protein in 223 specimens of nasopharyngeal carcinoma was examined by immunohistochemistry.Based on the levels of ku70 immunoreactivities,the 223 specimens were divided into high Ku70 expression group and low Ku70 expression group.The correlation of Ku70 expression with clinicopathologic features and prognosis of NPC was analyzed according to the clinical data. Results The rate of high Ku70 expression was 63.7%.Univariate survival analysis suggested that the overall survival rate was significantly lower in high KuTO expression group than in low Ku70 expression group (X2 = 7.88,P = 0.005).Cox multivariate analysis indicated that T stage,N stage and M stage were the independent prognostic predictors (X2 = 8.02,7.22,36.86;P =0.005,0.007,0.000),but not with gender, age or pathological type(X2 = 0.08 ,1.04,2.34;P = 0.780,0.308,0.126),the influence of Ku70 on the o verall survival rate was close to critical value(P = 0.085).Conclusions Ku70 is positively expressed in the majority of NPC.KuT0 expression has significant correlations with T stage and N stage.The results of our study suggest that Ku70 is a valuable prognostic factor of NPC.
