CAJ | 학술논문

目的探讨脑源性神经营养因子(BDNF)与血清5-羟色胺(5-HT)在伴学习障碍(LD)的注意缺陷多动障碍(ADHD)患儿中的作用及关系. 方法选择河南省精神卫生中心门诊及病房自2011年1月至2011年10月收治的ADHD患儿40例,其中伴LD患儿15例,不伴LD患儿25例,选择同期健康体检儿童25例作为正常对照组,比较3组受试者血清BDNF、5-HT的水平并分析ADHD伴LD组患儿血清BDNF及5-HT水平的相关性. 结果 ADHD伴LD组、ADHD不伴LD组及正常对照组BDNF水平依次降低,差异有统计学意义(P＜0.05)；与ADHD伴LD组比较,ADHD不伴LD组及正常对照组5-HT水平升高,差异有统计学意义(P＜0.05)；ADHD伴LD组患儿血清BDNF、5-HT水平呈负相关关系(r=-0.084,P=0.004). 结论伴LD的ADHD患儿中存在BDNF及5-HT异常,二者可能相互作用共同参与ADHD的病理过程.
목적 탐토뇌원성신경영양인자(BDNF)여혈청5-간색알(5-HT)재반학습장애(LD)적주의결함다동장애(ADHD)환인중적작용급관계. 방법 선택하남성정신위생중심문진급병방자2011년1월지2011년10월수치적ADHD환인40례,기중반LD환인15례,불반LD환인25례,선택동기건강체검인동25례작위정상대조조,비교3조수시자혈청BDNF、5-HT적수평병분석ADHD반LD조환인혈청BDNF급5-HT수평적상관성. 결과 ADHD반LD조、ADHD불반LD조급정상대조조BDNF수평의차강저,차이유통계학의의(P＜0.05)；여ADHD반LD조비교,ADHD불반LD조급정상대조조5-HT수평승고,차이유통계학의의(P＜0.05)；ADHD반LD조환인혈청BDNF、5-HT수평정부상관관계(r=-0.084,P=0.004). 결론 반LD적ADHD환인중존재BDNF급5-HT이상,이자가능상호작용공동삼여ADHD적병리과정.
Objective To explore the relationship between brain-derived neurotrophic factor (BDNF) and 5-hydroxytryptamine (5-HT) in children with attention deficit hyperactivity disorder (ADHD) plus learning disabilities (LD) and their effects. Methods The present study included 40ADHD children with (15 cases) or without LD (25 cases) who had presented to our institute from January 2011 to October 2011,and 25 healthy children as controls as well.The serum levels of BDNF and 5-HT were compared between the 3 groups.Analysis of variance and linear correlation model were used to assess the levels and correlation of BDNF and 5-HT in the ADHD + LD group. Results The BDNF level significantly decreased in turn from the ADHD+LD group to the ADHD group to the control group (P＜0.05). The 5-HT level significantly increased in the ADHD and control groups compared with the ADHD + LD group (P＜0.05).The serum levels of BDNF and 5-HT were negatively correlated in the ADHD + LD group (r=-0.084,P=0.004). Conclusion Since the serum levels of BDNF and 5-HT are abnormal in children with ADHD plus LD,they may interact with one another and get involved in the pathological process of ADHD.