CAJ | 학술논문

目的观察肝素钙预防过敏性紫癜患儿肾损害的临床疗效.方法选择过敏性紫癜患儿68例,随机分为肝素钙治疗组36例,对照组32例.肝素钙治疗组在常规治疗基础上加用肝素钙100 ～125 U/(kg·d),静脉滴注,连用7d,观察两组紫癜性肾炎发生的例数及治疗后1、6个月尿微量白蛋白(Alb),尿β2-微球蛋白(β2-MG)变化.结果平均随访6个月,肝素钙治疗组发生肾炎3例(8.3％),对照组发生肾炎9例(28.1％),肝素钙治疗组肾炎发生率明显低于对照组(P＜0.05),肝素钙治疗组治疗后1、6个月尿Alb、β2-MG量明显低于对照组(P＜0.01).结论肝素钙预防过敏性紫癜肾损害疗效确切,使用安全,值得临床推广.
목적 관찰간소개예방과민성자전환인신손해적림상료효.방법 선택과민성자전환인68례,수궤분위간소개치료조36례,대조조32례.간소개치료조재상규치료기출상가용간소개100 ～125 U/(kg·d),정맥적주,련용7d,관찰량조자전성신염발생적례수급치료후1、6개월뇨미량백단백(Alb),뇨β2-미구단백(β2-MG)변화.결과 평균수방6개월,간소개치료조발생신염3례(8.3％),대조조발생신염9례(28.1％),간소개치료조신염발생솔명현저우대조조(P＜0.05),간소개치료조치료후1、6개월뇨Alb、β2-MG량명현저우대조조(P＜0.01).결론 간소개예방과민성자전신손해료효학절,사용안전,치득림상추엄.
Objective To observe the clinical effect of heparin calcium on renal injury in patients with Henoch-Schoenlein purpura (HSP).Methods Sixty-eight patients with HSP were enrolled in the study and randomly divided into two groups,heparin calcium group (36 cases)and control group (32 cases).Heparin calcium group received heparin calcium by imravenous drip of 100-125 U/(kg · d) for7 days on the basis of conventional treatment,the numbers of developing HSPN were detected,Alb and β2-MG of urine were monitored after treatment for one month and six months.Results During six months follow-up,HSPN happened in heparin calcium group were 3 cases (8.3％) and 9 cases (28.l％)in control group,respectively ( P ＜0.05),Alb and β2-MG levels of the heparin calcium group were lower than those of the control group after treatment for one and six months( P ＜0.01 ).Conclusions Heparin calcium is safe and effective for preventing renal injury in patients with HSP,and is worthy to promoting in clinics.