临床麻醉学杂志
臨床痳醉學雜誌
림상마취학잡지
THE JOURNAL OF CLINICAL ANESTHESIOLOGY
2001年
3期
121-123
,共3页
葛宁花%薛张纲%蒋豪
葛寧花%薛張綱%蔣豪
갈저화%설장강%장호
全身麻醉%硬膜外%脑电双频指数%知晓%异丙酚
全身痳醉%硬膜外%腦電雙頻指數%知曉%異丙酚
전신마취%경막외%뇌전쌍빈지수%지효%이병분
目的 探讨硬膜外阻滞复合全身麻醉术中知晓的发生率以及脑电双频指数(BIS)与镇静深度的关系。方法 选择ASAⅠ~Ⅱ级的肝癌手术患者240例,麻醉方法均为硬膜外阻滞加全麻。分为两组:异丙酚组(P组,n=120),术前30分钟肌注苯巴比妥钠0.1g、阿托品0.3mg,诱导用芬太尼4μg/kg、异丙酚1.5mg/kg、琥珀胆碱2mg/kg,维持用异丙酚12mg.kg-1.h-1,持续15分钟后改为3mg.kg-1.h-1至术毕;硫喷妥钠组(T组,n=120),术前30分钟肌注咪唑安定0.075~0.1mg/kg、阿托品0.3mg,诱导用硫喷妥钠6mg/kg替换P组的异丙酚,其余药相同,维持用60%的N2O吸入至术毕。两组均在诱导前15分钟开始在硬膜外导管内注入0.5%布比卡因4ml。术中持续监测BIS和边缘频率(SEF)。结果 诱导前两组患者的EEG无差异;诱导后15分钟和30分钟,EEG抑制,BIS和SEF均降低,组间无差异;诱导后60分钟和120分钟,P组的BIS和SEF比T组低(P<0.05)。P组1例术中知晓。结论 联合麻醉中,用BIS监测预防术中知晓的发生缺乏精确性。
目的 探討硬膜外阻滯複閤全身痳醉術中知曉的髮生率以及腦電雙頻指數(BIS)與鎮靜深度的關繫。方法 選擇ASAⅠ~Ⅱ級的肝癌手術患者240例,痳醉方法均為硬膜外阻滯加全痳。分為兩組:異丙酚組(P組,n=120),術前30分鐘肌註苯巴比妥鈉0.1g、阿託品0.3mg,誘導用芬太尼4μg/kg、異丙酚1.5mg/kg、琥珀膽堿2mg/kg,維持用異丙酚12mg.kg-1.h-1,持續15分鐘後改為3mg.kg-1.h-1至術畢;硫噴妥鈉組(T組,n=120),術前30分鐘肌註咪唑安定0.075~0.1mg/kg、阿託品0.3mg,誘導用硫噴妥鈉6mg/kg替換P組的異丙酚,其餘藥相同,維持用60%的N2O吸入至術畢。兩組均在誘導前15分鐘開始在硬膜外導管內註入0.5%佈比卡因4ml。術中持續鑑測BIS和邊緣頻率(SEF)。結果 誘導前兩組患者的EEG無差異;誘導後15分鐘和30分鐘,EEG抑製,BIS和SEF均降低,組間無差異;誘導後60分鐘和120分鐘,P組的BIS和SEF比T組低(P<0.05)。P組1例術中知曉。結論 聯閤痳醉中,用BIS鑑測預防術中知曉的髮生缺乏精確性。
목적 탐토경막외조체복합전신마취술중지효적발생솔이급뇌전쌍빈지수(BIS)여진정심도적관계。방법 선택ASAⅠ~Ⅱ급적간암수술환자240례,마취방법균위경막외조체가전마。분위량조:이병분조(P조,n=120),술전30분종기주분파비타납0.1g、아탁품0.3mg,유도용분태니4μg/kg、이병분1.5mg/kg、호박담감2mg/kg,유지용이병분12mg.kg-1.h-1,지속15분종후개위3mg.kg-1.h-1지술필;류분타납조(T조,n=120),술전30분종기주미서안정0.075~0.1mg/kg、아탁품0.3mg,유도용류분타납6mg/kg체환P조적이병분,기여약상동,유지용60%적N2O흡입지술필。량조균재유도전15분종개시재경막외도관내주입0.5%포비잡인4ml。술중지속감측BIS화변연빈솔(SEF)。결과 유도전량조환자적EEG무차이;유도후15분종화30분종,EEG억제,BIS화SEF균강저,조간무차이;유도후60분종화120분종,P조적BIS화SEF비T조저(P<0.05)。P조1례술중지효。결론 연합마취중,용BIS감측예방술중지효적발생결핍정학성。
Objective To study the relationship between the awareness incombined epidural-general anesthesia and the bispectral index,spectral edge frequency of electroencephalogram.Methods 240 liver cancer patients were randomly divided into propofol (group P,n=120)and thiopentone (group T,n=120) groups.In group P,anesthesia was induced with propofol 1.5mg/kg and maintained with propofol 12mg.kg-1.h-1for 15 minutes and 3mg.kg-1.h-1 thereafter.In group T,thiopentone 6mg/kg was used to facilitate the induction and 60% N2O was inhaled to maintaine the anesthesia.All patients received epidural block during operations.The BIS was continuously monitored with computerized power spectral analysis device.Results There were no differences in BIS between two groups before induction.At 15 and 30 min after intubation, EEG was depressed slightly in both groups.Although BIS and SEF (60min and 120min after intubation)were lower in group P,one awareness happened during operation in P group.Conclusions Monitoring the BIS could not reliably prevent the happening of the awareness during operation in combined epidural-general anesthesia.