CAJ | 학술논문

目的探索CML患者的KIR(killer cell immunoglobulin-like receptors)基因的多态性与正常人群是否存在差异.方法应用PCR-SSP技术进行KIR基因的检测.结果共检出目前已知的18个KIR基因,在检测的全部个体中,3DL3, 3DL2及2DL4出现频率均为100%.在CML的研究中发现KIR2DL1基因频率(0.509)比正常对照组(1.000)显著降低,KIR2DL1与CML呈现强负相关P＜0.001,与CML负相关的KIR基因尚有3DS1,2DL5和3DL1, P值分别等于0.021,0.029,0.031.其他KIR基因位点频率未发现统计学差异.结论 CML患者具有其独特KIR基因位点频率的特点.
목적 탐색CML환자적KIR(killer cell immunoglobulin-like receptors)기인적다태성여정상인군시부존재차이.방법 응용PCR-SSP기술진행KIR기인적검측.결과 공검출목전이지적18개KIR기인,재검측적전부개체중,3DL3, 3DL2급2DL4출현빈솔균위100%.재CML적연구중발현KIR2DL1기인빈솔(0.509)비정상대조조(1.000)현저강저,KIR2DL1여CML정현강부상관P＜0.001,여CML부상관적KIR기인상유3DS1,2DL5화3DL1, P치분별등우0.021,0.029,0.031.기타KIR기인위점빈솔미발현통계학차이.결론 CML환자구유기독특KIR기인위점빈솔적특점.