CAJ | 학술논문

目的探讨慢性肾脏病(CKD)并发医院真菌感染(NFI)情况及其易感因素.方法评价CKD并发NFI的真菌特征和实验室指标与NFI的关系.结果 65例CKD并发NFI者中最常见的感染部位是泌尿道25例次(38.46%),其次是消化道20例次(30.77%);最常见的病原菌是白色念珠菌50例次(68.49%),其次是热带念珠菌13例次(17.81%);白色念珠菌对氟康唑的敏感率为90%.易感因素有住院时间长、贫血、营养不良、低IgG血症、大量蛋白尿、肾功能不全、大剂量使用激素、环磷酰胺和广谱抗生素等.结论 CKD易并发NFI,最常见的病原菌是白色念珠菌,控制易感因素是预防NFI的有效方法 .
목적 탐토만성신장병(CKD)병발의원진균감염(NFI)정황급기역감인소.방법 평개CKD병발NFI적진균특정화실험실지표여NFI적관계.결과 65례CKD병발NFI자중최상견적감염부위시비뇨도25례차(38.46%),기차시소화도20례차(30.77%);최상견적병원균시백색념주균50례차(68.49%),기차시열대념주균13례차(17.81%);백색념주균대불강서적민감솔위90%.역감인소유주원시간장、빈혈、영양불량、저IgG혈증、대량단백뇨、신공능불전、대제량사용격소、배린선알화엄보항생소등.결론 CKD역병발NFI,최상견적병원균시백색념주균,공제역감인소시예방NFI적유효방법 .
Objective To investigate the predisposing factors and fungal characteristics of nosocomial fungal infection (NFI) in patients with chronic kidney disease (CKD). Methods The fungal characteristics and laboratory indices were analyzed in patients with and without NFI secondary to CKD. Results The most common infection site of NFI in 65 cases patients with CKD was urinary tract (25 man-times, 38.46%), and the second common site was digestive tract (20 man-times, 30.77%). The most common pathogenic fungus was Candida albicans (68.49%), followed by Candida tropicalis (17.81%). The sensitivity of Candida albicans to fluconazol was 90%. The predisposing factors included prolonged length of stay, anaemia, malnutrition, hypogammaglobulinemia, mass proteinuria, renal insufficiency, and the use of large dose of broad spectrum antibiotics, prednisone and cytoxan. Conclusion CKD may predispose to NFI, and the most common fungus is Candida albicans,so the predisposing factors should be controlled so as to prevent NFI among patients with CKD.