临床皮肤科杂志
臨床皮膚科雜誌
림상피부과잡지
JOURNAL OF CLINICAL DERMATOLOGY
2010年
2期
127-129
,共3页
白癜风%他克莫司%紫外线,窄谱,中波
白癜風%他剋莫司%紫外線,窄譜,中波
백전풍%타극막사%자외선,착보,중파
vitiligo%tacmlimus%NB-UVB
目的:评价外用0.1%他克莫司软膏联合窄谱中波紫外线(NB-UVB)治疗面、颈部白癜风的临床疗效和不良反应.方法:将82例面颈部自癜风患者随机分成3组.A组:外用0.1%他克莫司软膏联合NB-UVB照射.B组:单独给予NB-UVB照射.C组:单独外用0.1%他克莫司软膏.疗程均为16周.试验结束时依据治疗前、后患者皮损的照片进行疗效评价.结果:治疗结束后,A、B、C3组有效率分别为78.6%(22/28),48.1%(13/27),51.9%(14/27);A组有效率与B、C两组相比.差异有统计学意义(P值均<0.05).A组与C组的复色开始平均时间相比,差异无统计学意义(P>0.05),但二者分别与B组相比,差异均有统计学意义(P值均<0.05).A组、c组中患者不同分期皮损的有效率差异有统计学意义(P<0.05),B组差异则无统计学意义(P>0.05).3组患者中不同部位皮损的疗效比较差异均无统计学意义(P值均>0.05).3组患者治疗部位出现灼热感、瘙痒的概率很低,且症状轻微.结论:他克莫司软膏治疗面、颈部白癜风起效快、疗效好、不良反应少,联合NB-UVB照射能进一步提高疗效.
目的:評價外用0.1%他剋莫司軟膏聯閤窄譜中波紫外線(NB-UVB)治療麵、頸部白癜風的臨床療效和不良反應.方法:將82例麵頸部自癜風患者隨機分成3組.A組:外用0.1%他剋莫司軟膏聯閤NB-UVB照射.B組:單獨給予NB-UVB照射.C組:單獨外用0.1%他剋莫司軟膏.療程均為16週.試驗結束時依據治療前、後患者皮損的照片進行療效評價.結果:治療結束後,A、B、C3組有效率分彆為78.6%(22/28),48.1%(13/27),51.9%(14/27);A組有效率與B、C兩組相比.差異有統計學意義(P值均<0.05).A組與C組的複色開始平均時間相比,差異無統計學意義(P>0.05),但二者分彆與B組相比,差異均有統計學意義(P值均<0.05).A組、c組中患者不同分期皮損的有效率差異有統計學意義(P<0.05),B組差異則無統計學意義(P>0.05).3組患者中不同部位皮損的療效比較差異均無統計學意義(P值均>0.05).3組患者治療部位齣現灼熱感、瘙癢的概率很低,且癥狀輕微.結論:他剋莫司軟膏治療麵、頸部白癜風起效快、療效好、不良反應少,聯閤NB-UVB照射能進一步提高療效.
목적:평개외용0.1%타극막사연고연합착보중파자외선(NB-UVB)치료면、경부백전풍적림상료효화불량반응.방법:장82례면경부자전풍환자수궤분성3조.A조:외용0.1%타극막사연고연합NB-UVB조사.B조:단독급여NB-UVB조사.C조:단독외용0.1%타극막사연고.료정균위16주.시험결속시의거치료전、후환자피손적조편진행료효평개.결과:치료결속후,A、B、C3조유효솔분별위78.6%(22/28),48.1%(13/27),51.9%(14/27);A조유효솔여B、C량조상비.차이유통계학의의(P치균<0.05).A조여C조적복색개시평균시간상비,차이무통계학의의(P>0.05),단이자분별여B조상비,차이균유통계학의의(P치균<0.05).A조、c조중환자불동분기피손적유효솔차이유통계학의의(P<0.05),B조차이칙무통계학의의(P>0.05).3조환자중불동부위피손적료효비교차이균무통계학의의(P치균>0.05).3조환자치료부위출현작열감、소양적개솔흔저,차증상경미.결론:타극막사연고치료면、경부백전풍기효쾌、료효호、불량반응소,연합NB-UVB조사능진일보제고료효.
Objective:To evaluate the efficacy and safety of topical tacrelimus 0.1%creanl and NB-UVB for the treatment of vitiligo on the face and neck. Methods:A randomized experimental controlled study was performed in 82 patients,they were randomly divided into three groups:group A,receiving topical tacrolimus 0.1%creanl as well as NB-UVB thempy;group B,singly receiving NB-UVB thempy;group C,sinOy receiving topical tacrolimus 0.1%.All patients were treated for 16 weeks.Efficacy was analyzed using digital photography taken before and after treatment. Results:After therapy,the re-sponse rates were 78.6%, 48.1%and 51.9%respectively in group A, B and C.The response rate waft,higher in group A than in group B and C(both P<0.05).The average time of color restoration was longer in group B than that of group A and C(both P<0.05),but there Wus no difference between group A and C.The response rates of different period were different in group A(P<0.05),and also in group C(P<0.05),but not in group B(P>0.05).The response rate of lesions on the face had no difference with lesions on the neck among all patients.Patients hardly appeared burning sensation and itching. Conclusions:Topical tacmlimus ointment is safe, effective and well-tolerated for vitiligo on the face and neck,The combination age of topical tacrolimus and NB-UVB may impmve its efficacy.
