CAJ | 학술논문

目的探讨ICU的院内真菌性败血症的临床特点、药敏情况及防治策略.方法收集2001-2006年我院ICU的院内获得性真菌性败血症55例进行回顾性分析.结果 55例患者血培养共分离出58株真菌菌株,非白色念珠菌比例高达74.54%.药敏分析显示:两性霉素B敏感率最高,其次为5-氟胞嘧啶,氟康唑对非白色念珠菌敏感率低.92.72%的患者有3种或以上的易患因素,总病死率50.91%.结论 ICU的院内获得性真菌性败血症致病菌株以非白色念珠菌为主,对氟康唑的耐药性增加,病死率高.消除易患因素,加强真菌药敏监测,合理使用抗真菌药物有助于改善预后.
목적 탐토ICU적원내진균성패혈증적림상특점、약민정황급방치책략.방법 수집2001-2006년아원ICU적원내획득성진균성패혈증55례진행회고성분석.결과 55례환자혈배양공분리출58주진균균주,비백색념주균비례고체74.54%.약민분석현시:량성매소B민감솔최고,기차위5-불포밀정,불강서대비백색념주균민감솔저.92.72%적환자유3충혹이상적역환인소,총병사솔50.91%.결론 ICU적원내획득성진균성패혈증치병균주이비백색념주균위주,대불강서적내약성증가,병사솔고.소제역환인소,가강진균약민감측,합리사용항진균약물유조우개선예후.
Objective To study the clinical characteristics, sensitivity analysis and treatment strategies of nescomial fangahnia in critical ill patients. Method Retrospective investigation of 55 consecutive ICU patients with noscomical fungalmia. Results 58 fungal strains were isolated from blood in 55 patients. The proportion of non-albicans species reached to 74.54%. In a sensitivity analysis, the sensitivity of amphotericin B was the best. Fluconazole-resistant candidiasis increased. 92.72% patients had three or more predisposing factors. Over all mortality was 50.91%. Conclutions In noscomical fungalmia, the proportion of non-albicans species and fluconazole-resistant candidiasis increase and mortality is high. Removing predisposing factors, monitoring fungal pathogen and sensitivity analysis, correctly antifungal therapy are more important to improve patients' prognosis.