CAJ | 학술논문

目的探讨原发性高血压和肾性高血压患者血管紧张素Ⅱ2型受体基因A1675G单核苷酸多态性与高血压发生的关系.方法应用直接测序方法对80例原发性高血压、80例肾性高血压和40名正常人群中血管紧张素Ⅱ2型受体基因作SNP分型.结果原发性高血压组A等位基因频率56.88％ (91/160),对照组30.00％ (24/80),差异有统计学意义(x2=15.44,P＜0.001)；A等位基因频率与肾性高血压无关联[42.50％ (68/160)与30.00％ (24/80),x2=3.52,P＞0.05).基因型分析原发性高血压和肾性高血压差异均无统计学意义(P均＞0.05).结论血管紧张素Ⅱ2型受体基因的A1675G单核苷酸多态性与原发性高血压发病有关.与肾性高血压无关.
목적 탐토원발성고혈압화신성고혈압환자혈관긴장소Ⅱ2형수체기인A1675G단핵감산다태성여고혈압발생적관계.방법 응용직접측서방법대80례원발성고혈압、80례신성고혈압화40명정상인군중혈관긴장소Ⅱ2형수체기인작SNP분형.결과 원발성고혈압조A등위기인빈솔56.88％ (91/160),대조조30.00％ (24/80),차이유통계학의의(x2=15.44,P＜0.001)；A등위기인빈솔여신성고혈압무관련[42.50％ (68/160)여30.00％ (24/80),x2=3.52,P＞0.05).기인형분석원발성고혈압화신성고혈압차이균무통계학의의(P균＞0.05).결론 혈관긴장소Ⅱ2형수체기인적A1675G단핵감산다태성여원발성고혈압발병유관.여신성고혈압무관.
Objective To study the relationship between angiotensin Ⅱ type 2 receptor (AGTR2) gene single nucleotide polymorphisms and hypertension in patients with essential hypertension and renal hypertension.Methods Direct DNA sequencing was performed to detect the single nucleotide polymorphisms (SNP) in eighty patients with essential hypertension,eighty patients with renal hypertension and forty normal blood pressure controls.Results There was significant difference on A allele frequencies between essential hypertension group and control group ( 56.88％ [ 91/160 ] vs 30.00％ [ 24/80 ],x2 =15.44,P ＜ 0.001 ).A allele frequency had no correlation with renal hypertension (42.50％ [ 68/160 ] vs 30.00％ [ 24/80 ],x2 =3.52,P ＞0.05).There was no significant difference on SNP between essential hypertension group and renal hypertension group ( P ＞ 0.05 ).Conclusion A1675G signal nucleotide polymorphisms of AGTR2 may be associated with the development of essential hypertension,but has nothing to do with renal hypertension.