CAJ | 학술논문

目的探讨胰腺癌组织中血管生长因子-D(VEGF-D)和基质金属蛋白酶-2(MMP-2)的表达与肿瘤侵袭转移的关系.方法应用免疫组化SABC法检测VEGF-D和MMP-2在30例胰腺癌和6例正常胰腺组织中的表达.结果胰腺癌组织中VEGF-D和MMP-2的高表达率分别为60%(18/30)和66.7%(20/30),而正常胰腺组织中未检测到VEGF-D和MMP-2的表迭.VEGF-D的高表达率与淋巴结转移密切相关(P＜0.05),MMP-2的高表达率与淋巴结转移和肿块浸润程度有关(P＜0.05).二者在胰腺癌组织中的表达呈正相关(rs=0.54,P＜0.01).结论胰腺癌中有VEGF-D和MMP-2的高表达,二者表达呈正相关,与胰腺癌的侵袭转移关系密切.
목적 탐토이선암조직중혈관생장인자-D(VEGF-D)화기질금속단백매-2(MMP-2)적표체여종류침습전이적관계.방법 응용면역조화SABC법검측VEGF-D화MMP-2재30례이선암화6례정상이선조직중적표체.결과 이선암조직중VEGF-D화MMP-2적고표체솔분별위60%(18/30)화66.7%(20/30),이정상이선조직중미검측도VEGF-D화MMP-2적표질.VEGF-D적고표체솔여림파결전이밀절상관(P＜0.05),MMP-2적고표체솔여림파결전이화종괴침윤정도유관(P＜0.05).이자재이선암조직중적표체정정상관(rs=0.54,P＜0.01).결론 이선암중유VEGF-D화MMP-2적고표체,이자표체정정상관,여이선암적침습전이관계밀절.
Objective To investigate the expression of VEGF-D and MMP-2 and explore their relationship with tumor invasion and local metastasis in pancreatic carcinoma.Methods The expression of VEGF-D and MMP-2 in 30 patients with pancreatic carcinomas and 6 cases with normal pancreatic tissues were detected by SABC immunohistochemical method.Results The positive rates of VEGF-D and MMP-2 proteins were 60%(18/30)and 66.7%(20/30)respectively,no expression of VEGF-D and MMP-2 was detected in normal pancreatie tissues.The expression of VEGF-D was significantly correlated with lymph node metastasis(P＜0.05),and the expression of MMP-2 was significantly correlated with lymph node metastasis and tumor local invasion(P＜0.05).The expression of VEGF-D protein Was positively correlated with MMP-2 protein(rs=0.54,P＜0.01).Conclusions There is a significantly positive correlation between high expression of VEGF-D and MMP-2 proteins in pancreatic carcinoma,and they may contribute to the invasive properties of pancreatic cancer.