CAJ | 학술논문

目的探讨丙戊酸钠治疗外伤性癫癎复发后,比较添加卡马西平或拉莫三嗪联合治疗外伤性癫癎效果.方法　采用开放性试验的方法对131例丙戊酸钠治疗外伤性癫癎复发患者,进行卡马西平或拉莫三嗪联合丙戊酸钠治疗,以治疗前3个月癫癎发作频度为对照,对治疗6个月后的疗效、不良反应及安全性进行自身对比观察.结果　应用卡马西平或拉莫三嗪联合丙戊酸钠治疗6个月后,患者发作频率均较用药前明显减少；发作频率减少≥50％的患者分别为72.6％和91.3％,差异有统计学意义(P＜0.01)；卡马西平联合丙戊酸钠不良反应的发生率为37.1％,拉莫三嗪联合丙戊酸钠不良反应的发生率为8.7％.结论　拉莫三嗪联合丙戊酸钠治疗外伤性癫癎复发疗效确切,不良反应轻微.
목적 탐토병무산납치료외상성전간복발후,비교첨가잡마서평혹랍막삼진연합치료외상성전간효과.방법　채용개방성시험적방법대131례병무산납치료외상성전간복발환자,진행잡마서평혹랍막삼진연합병무산납치료,이치료전3개월전간발작빈도위대조,대치료6개월후적료효、불량반응급안전성진행자신대비관찰.결과　응용잡마서평혹랍막삼진연합병무산납치료6개월후,환자발작빈솔균교용약전명현감소；발작빈솔감소≥50％적환자분별위72.6％화91.3％,차이유통계학의의(P＜0.01)；잡마서평연합병무산납불량반응적발생솔위37.1％,랍막삼진연합병무산납불량반응적발생솔위8.7％.결론　랍막삼진연합병무산납치료외상성전간복발료효학절,불량반응경미.
Objective To explore the effect of depakine in the treatment of traumatic epilepsy relapse,and compared carbamazepine and lamotrigine combined with depakine in the treatment of traumatic epilepsy.Methods Open trial in 131 patients with traumatic epilepsy relapse treated with depakine,and all patients were aderministered with carbamazepine or lamotrigine combined with depakine.3 months before treatment,the epilepsy seizures frequency was compared,and 6 months after the treatment,the efficacy,adverse reactions and safety was compared between two mothods.Results Application of carbamazepine or lamotrigine combined with depakine treatment for 6 months,the seizure frequency significantly decreased compared with before treatment;The seizure frequency reduction( ≥50％ ) were 72.6％ and 91.3％,the difference was statistically significant between before and after treatment( P ＜ 0.01 ) ;The adverse reactions of carbamazepine combined with depakine was 37.1％,and it of lamotrigine combined with depakine was 8.7％.Conclusion Lamotrigine combined with depakine in the treatment of traumatic epilepsy recurrence was effective,and its side effects was light.