CAJ | 학술논문

目的探讨我国职业接触二硫化碳(CS2)的生物接触限值.方法用高效液相色谱法测定工人班末尿中2-硫代噻唑烷-4-羧酸(TTCA)含量,用气相色谱法测定接触CS2工人作业场所空气中CS2浓度,探讨二者的相关关系,比较生物接触限值和PC-TWA判定结果.结果 CS2作业工人班末尿中TTCA含量与其接触的工作场所空气中CS2浓度呈正相关,回归方程式Y=0.265X-0.165 (r=0.91,P＜0.01).基于本次研究的回归方程,根据GBZ 2.1-2007《工作场所有害因素职业接触限值第1部分:化学有害因素》规定的CS2的PC-TWA 5 mg/m3推算,CS2接触工人班末尿中TTCA浓度生物限值为1.2 mgTTCA/g Cr.结论建议我国CS2生物接触限值修订为1.2 mg TTCA/g Cr.
목적 탐토아국직업접촉이류화탄(CS2)적생물접촉한치.방법 용고효액상색보법측정공인반말뇨중2-류대새서완-4-최산(TTCA)함량,용기상색보법측정접촉CS2공인작업장소공기중CS2농도,탐토이자적상관관계,비교생물접촉한치화PC-TWA판정결과.결과 CS2작업공인반말뇨중TTCA함량여기접촉적공작장소공기중CS2농도정정상관,회귀방정식Y=0.265X-0.165 (r=0.91,P＜0.01).기우본차연구적회귀방정,근거GBZ 2.1-2007《공작장소유해인소직업접촉한치제1부분:화학유해인소》규정적CS2적PC-TWA 5 mg/m3추산,CS2접촉공인반말뇨중TTCA농도생물한치위1.2 mgTTCA/g Cr.결론 건의아국CS2생물접촉한치수정위1.2 mg TTCA/g Cr.
Objective To study the biological exposure index of carbon disulfide in china.Methods High-performance liquid chromatography (HPLC) was used to detect the levels of 2-thiothiazolidine-4-carboxylic acid (TTCA) in the urine of the workers after working shift end,Gas chromatography was used to detect the concentrations of the carbon disulfide in the workplace air.The relationship between the urine TTCA levels and the concentrations of the carbon disulfide was analyzed,the biological exposure index and judgement result from pC-TWA were compared.Results The levels of TTCA in urine of workers occupationally exposed to carbon disulfide were closely and positively related with the concentrations of the carbon disulfide in the workplace air.The regression equation was Y=0.265X-0.165,The biological exposure index of carbon disulfide were calculated by regression equation according to occupational exposure limits of carbon disulfide in China.Conclusion The biological exposure index of CS2 in China might be rersived for 1.2 mg/g Cr.