CAJ | 학술논문

目的观察阿托伐他汀联合氯吡格雷对老年脑梗死患者颈动脉粥样斑块的治疗效果.方法选择河南省人民医院神经内科自2006年7月至2010年9月收治的老年脑梗死患者80例,其中联合应用阿托伐他汀和氯吡格雷治疗40例(观察组),单纯使用氯吡格雷治疗40例(对照组),治疗后4、12、24周检查患者三酰甘油(TG)、血清总胆固醇(CH)、低密度脂蛋白胆固醇(LDL-C)、乳酸脱氢酶(LDH)、血粘滞度及血小板最大聚集率(MAR)并评定斑块积分.结果与治疗前比较,治疗后24周对照组患者TG、LDL-C、MAR,12周观察组患者TG、CH,24周观察组患者TG、CH、LDL-C、MAR均降低,差异有统计学意义(P<0.05);与对照组比较,观察组患者治疗后12周CH,治疗后24周TG、CH、LDL-C较低,差异有统计学意义(P<0.05);与对照组比较,治疗后24周观察组患者粥样斑块积分较低.差异有统计学意义(P<0.05).结论联合应用阿托伐他汀联合氯吡格雷可以稳定老年脑梗死患者颈动脉粥样硬化斑块,且安全可靠.
목적 관찰아탁벌타정연합록필격뢰대노년뇌경사환자경동맥죽양반괴적치료효과.방법 선택하남성인민의원신경내과자2006년7월지2010년9월수치적노년뇌경사환자80례,기중연합응용아탁벌타정화록필격뢰치료40례(관찰조),단순사용록필격뢰치료40례(대조조),치료후4、12、24주검사환자삼선감유(TG)、혈청총담고순(CH)、저밀도지단백담고순(LDL-C)、유산탈경매(LDH)、혈점체도급혈소판최대취집솔(MAR)병평정반괴적분.결과 여치료전비교,치료후24주대조조환자TG、LDL-C、MAR,12주관찰조환자TG、CH,24주관찰조환자TG、CH、LDL-C、MAR균강저,차이유통계학의의(P<0.05);여대조조비교,관찰조환자치료후12주CH,치료후24주TG、CH、LDL-C교저,차이유통계학의의(P<0.05);여대조조비교,치료후24주관찰조환자죽양반괴적분교저.차이유통계학의의(P<0.05).결론 연합응용아탁벌타정연합록필격뢰가이은정노년뇌경사환자경동맥죽양경화반괴,차안전가고.
Objective To observe the clinical effects of atorvastatin combined with clopidogrel on the prevention of carotid artery atherosclerostic plaques in aged patients with infarction. Methods Eighty aged patients with infarction, admitted to out hospital from July 2006 to September 2010, were chosen; these patients were randomly divided into observation group (n=40, giving treatment of atorvastatin combined with clopidogrel) and control group (n=40, giving treatment of treatment of Clopidogrel). The levels of triglyceride (TG), total cholesterol (CH), low-density lipoprotein cholesterol (LDL-C) and lactate dehydrogenase (LDH), the blood viscosity and the platelet maximum aggregation rate (MAR) were measured and the plaque scores were evaluated 4, 12 and 24 w after the treatment.Results As compared with those before treatment, the levels of TG, LDL-C and MAR in the control group 24 w after treatment, and the levels of TG and CH in the observation group 12 w after treatment and the levels of TG, CH, LDL-C and MAR in the observation group 24 w after the treatment were significantly decreased (P<0.05). As compared with the control group, the observation group enjoyed significantly lower level of CH 12w after the treatment and lower levels of TG, CH and LDL-C 24 w after the treatment (P<0.05). Lower plaque scores in the observation group were noted as compared with that in the control group 24 w after the treatment (P<0.05). Conclusion Atorvastatin combined with clopidogrel can safely prevent and stabilize the carotid artery atherosclerostic plaques in aged patients with infarction.