中华妇产科杂志
中華婦產科雜誌
중화부산과잡지
CHINESE JOUNAL OF OBSTETRICS AND GYNECOLOGY
2001年
4期
206-208
,共3页
晋丽平%WANG Chenhong
晉麗平%WANG Chenhong
진려평%WANG Chenhong
妊娠并发症,心血管%高血压%神经肽Y
妊娠併髮癥,心血管%高血壓%神經肽Y
임신병발증,심혈관%고혈압%신경태Y
目的 探讨妊娠高血压综合征(妊高征)患者血浆神经肽Y(NPY)水平的变化及其与妊高征发病的关系。方法 采用放射免疫分析法测定了30例妊高征患者(妊高征组)产前及产后、23例正常妊娠妇女(正常妊娠组)和20例正常育龄未孕妇女(正常非孕组)血浆NPY水平。结果 妊高征组产前血浆NPY水平［(164.16±68.32) ng/L］明显高于正常非孕组［(86.60±20.65) ng/L］和正常妊娠组［(82.42±12.46) ng/L］(P<0.01)。妊高征组轻、中、重患者之间，产前血浆NPY水平有显著差异，分别为(88.66±25.69) ng/L、(145.15±18.72) ng/L、(235.05±33.60) ng/L(P<0.01)。妊高征组中、重度患者产前与产后血浆NPY水平分别为(80.04±28.70) ng/L及(130.43±37.38) ng/L，两者比较，差异有显著性(P<0.01)；重度患者产后NPY水平仍明显高于正常妊娠组(P<0.01)。 结论 妊高征患者血浆NPY水平增高，NPY参与了妊高征的发生和发展。
目的 探討妊娠高血壓綜閤徵(妊高徵)患者血漿神經肽Y(NPY)水平的變化及其與妊高徵髮病的關繫。方法 採用放射免疫分析法測定瞭30例妊高徵患者(妊高徵組)產前及產後、23例正常妊娠婦女(正常妊娠組)和20例正常育齡未孕婦女(正常非孕組)血漿NPY水平。結果 妊高徵組產前血漿NPY水平［(164.16±68.32) ng/L］明顯高于正常非孕組［(86.60±20.65) ng/L］和正常妊娠組［(82.42±12.46) ng/L］(P<0.01)。妊高徵組輕、中、重患者之間，產前血漿NPY水平有顯著差異，分彆為(88.66±25.69) ng/L、(145.15±18.72) ng/L、(235.05±33.60) ng/L(P<0.01)。妊高徵組中、重度患者產前與產後血漿NPY水平分彆為(80.04±28.70) ng/L及(130.43±37.38) ng/L，兩者比較，差異有顯著性(P<0.01)；重度患者產後NPY水平仍明顯高于正常妊娠組(P<0.01)。 結論 妊高徵患者血漿NPY水平增高，NPY參與瞭妊高徵的髮生和髮展。
목적 탐토임신고혈압종합정(임고정)환자혈장신경태Y(NPY)수평적변화급기여임고정발병적관계。방법 채용방사면역분석법측정료30례임고정환자(임고정조)산전급산후、23례정상임신부녀(정상임신조)화20례정상육령미잉부녀(정상비잉조)혈장NPY수평。결과 임고정조산전혈장NPY수평［(164.16±68.32) ng/L］명현고우정상비잉조［(86.60±20.65) ng/L］화정상임신조［(82.42±12.46) ng/L］(P<0.01)。임고정조경、중、중환자지간，산전혈장NPY수평유현저차이，분별위(88.66±25.69) ng/L、(145.15±18.72) ng/L、(235.05±33.60) ng/L(P<0.01)。임고정조중、중도환자산전여산후혈장NPY수평분별위(80.04±28.70) ng/L급(130.43±37.38) ng/L，량자비교，차이유현저성(P<0.01)；중도환자산후NPY수평잉명현고우정상임신조(P<0.01)。 결론 임고정환자혈장NPY수평증고，NPY삼여료임고정적발생화발전。
Objective To investigate the changes and its clinical significance of plasma neuropeptide Y(NPY) concentration in patients with pregnancy induced hypertension (PIH). Methods Plasma NPY levels were detected by radioimmunoassay in 30 patients with PIH, 20 normal non-pregnant women and 23 normal pregnant women. The PIH group was subdivided into mild, moderate and Severe subgroups, and the NPY concentration was also measured in these subgroups respectively at admission and one week after delivery. Results The plasma NPY levels in patients with PIH ［(164.16±68.32) ng/L］ were significantly higher than those of normal non-pregnant women and normal pregnancies ［(86.60±20.65) ng/L, (82.42±12.46) ng/L, P<0.01, respectively］. There was significant difference among plasma NPY levels among the patients with mild, moderate, and severe PIH at admission (P<0,01). At one week after delivery the concentrations of plasma NPY were significantly decreased in the moderate and severe subgroups compared with the value measured at admission (P<0.01). Moreover, the NPY levels in patients with severe PIH after delivery were still higher than those of normal non-pregnant women. Conclusions The results suggested that the level of NPY in plasma is increased in women with PIH. Elevated plasma NPY levels may play a key role in the development of PIH.
